dc.contributor.author | Davey, NE | |
dc.contributor.author | Simonetti, L | |
dc.contributor.author | Ivarsson, Y | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2023-08-04T13:38:22Z | |
dc.date.available | 2023-08-04T13:38:22Z | |
dc.date.issued | 2023-06-01 | |
dc.identifier | ARTN 102593 | |
dc.identifier | S0959-440X(23)00067-2 | |
dc.identifier.citation | Current Opinion in Structural Biology, 2023, 80 pp. 102593 - | en_US |
dc.identifier.issn | 0959-440X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5931 | |
dc.identifier.eissn | 1879-033X | |
dc.identifier.eissn | 1879-033X | |
dc.identifier.doi | 10.1016/j.sbi.2023.102593 | |
dc.description.abstract | Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules that perform key regulatory functions and drive dynamic complex formation. For decades, interactions mediated by SLiMs have accumulated through detailed low-throughput experiments. Recent methodological advances have opened this previously underexplored area of the human interactome to high-throughput protein-protein interaction discovery. In this article, we discuss that SLiM-based interactions represent a significant blind spot in the current interactomics data, introduce the key methods that are illuminating the elusive SLiM-mediated interactome of the human cell on a large scale, and discuss the implications for the field. | |
dc.format | Print-Electronic | |
dc.format.extent | 102593 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | CURRENT BIOLOGY LTD | en_US |
dc.relation.ispartof | Current Opinion in Structural Biology | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.subject | High-throughput methods | |
dc.subject | Interactomics | |
dc.subject | Protein–peptide interactions | |
dc.subject | Protein–protein interactions | |
dc.subject | Short linear motifs (SLiMs) | |
dc.subject | Humans | |
dc.subject | Proteome | |
dc.subject | Amino Acid Motifs | |
dc.title | The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-03-17 | |
dc.date.updated | 2023-08-04T13:37:54Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1016/j.sbi.2023.102593 | en_US |
rioxxterms.licenseref.startdate | 2023-06-01 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/37099901 | |
pubs.organisational-group | /ICR | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.sbi.2023.102593 | |
pubs.volume | 80 | |
icr.researchteam | Short Linear Motif | en_US |
dc.contributor.icrauthor | Davey, Norman | |
icr.provenance | Deposited by Mr Arek Surman on 2023-08-04. Deposit type is initial. No. of files: 1. Files: 1-s2.0-S0959440X23000672-main.pdf | |