SLiM-binding pockets: an attractive target for broad-spectrum antivirals.
Date
2023-01-07ICR Author
Author
Simonetti, L
Nilsson, J
McInerney, G
Ivarsson, Y
Davey, NE
Type
Journal Article
Metadata
Show full item recordAbstract
Short linear motif (SLiM)-mediated interactions offer a unique strategy for viral intervention due to their compact interfaces, ease of convergent evolution, and key functional roles. Consequently, many viruses extensively mimic host SLiMs to hijack or deregulate cellular pathways and the same motif-binding pocket is often targeted by numerous unrelated viruses. A toolkit of therapeutics targeting commonly mimicked SLiMs could provide prophylactic and therapeutic broad-spectrum antivirals and vastly improve our ability to treat ongoing and future viral outbreaks. In this opinion article, we discuss the therapeutic relevance of SLiMs, advocating their suitability as targets for broad-spectrum antiviral inhibitors.
Collections
Subject
inhibitors
protein–protein interactions
short linear motifs
viral outbreak preparedness
viruses
Research team
Short Linear Motif
Language
eng
Date accepted
2022-12-15
License start date
2023-01-07
Citation
Trends in Biochemical Sciences, 2023, pp. S0968-0004(22)00332-2 -
Publisher
CELL PRESS