Browsing by author "Blackledge, Matthew"
Now showing items 21-40 of 42
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Multiparametric bone MRI can improve CT-guided bone biopsy target selection in cancer patients and increase diagnostic yield and feasibility of next-generation tumour sequencing.
Donners, R; Figueiredo, I; Tunariu, N; Blackledge, M; Koh, D-M; et al. (SPRINGER, 2022-01-29)OBJECTIVES: To evaluate whether multiparametric bone MRI (mpBMRI) utilising a combination of DWI signal, ADC and relative fat-fraction (rFF) can identify bone metastases, which provide high diagnostic biopsy yield and ... -
Noise-Corrected, Exponentially Weighted, Diffusion-Weighted MRI (niceDWI) Improves Image Signal Uniformity in Whole-Body Imaging of Metastatic Prostate Cancer.
Blackledge, MD; Tunariu, N; Zungi, F; Holbrey, R; Orton, MR; et al. (FRONTIERS MEDIA SA, 2020-05-08)Purpose: To characterize the voxel-wise uncertainties of Apparent Diffusion Coefficient (ADC) estimation from whole-body diffusion-weighted imaging (WBDWI). This enables the calculation of a new parametric map based on ... -
Non-contrast CT synthesis using patch-based cycle-consistent generative adversarial network (Cycle-GAN) for radiomics and deep learning in the era of COVID-19.
Kalantar, R; Hindocha, S; Hunter, B; Sharma, B; Khan, N; et al. (NATURE PORTFOLIO, 2023-06-29)Handcrafted and deep learning (DL) radiomics are popular techniques used to develop computed tomography (CT) imaging-based artificial intelligence models for COVID-19 research. However, contrast heterogeneity from real-world ... -
Noninvasive MRI Native T1 Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma.
Zormpas-Petridis, K; Poon, E; Clarke, M; Jerome, NP; Boult, JKR; et al. (AMER ASSOC CANCER RESEARCH, 2020-08-15)Noninvasive early indicators of treatment response are crucial to the successful delivery of precision medicine in children with cancer. Neuroblastoma is a common solid tumor of young children that arises from anomalies ... -
Optimisation of b-values for the accurate estimation of the apparent diffusion coefficient (ADC) in whole-body diffusion-weighted MRI in patients with metastatic melanoma.
Knill, AK; Blackledge, MD; Curcean, A; Larkin, J; Turajlic, S; et al. (SPRINGER, 2022-09-28)OBJECTIVE: To establish optimised diffusion weightings ('b-values') for acquisition of whole-body diffusion-weighted MRI (WB-DWI) for estimation of the apparent diffusion coefficient (ADC) in patients with metastatic ... -
Optimising CT-guided biopsies of sclerotic bone lesions in cancer patients.
Donners, R; Fotiadis, N; Figueiredo, I; Blackledge, M; Westaby, D; et al. (SPRINGER, 2022-07-26)OBJECTIVES: Investigate the laboratory, imaging and procedural factors that are associated with a tumour-positive and/or NGS-feasible CT-guided sclerotic bone lesion biopsy result in cancer patients. METHODS: In total, 113 ... -
Prospective Evaluation of Whole-Body MRI versus FDG PET/CT for Lesion Detection in Participants with Myeloma.
Messiou, C; Porta, N; Sharma, B; Levine, D; Koh, D-M; et al. (RADIOLOGICAL SOC NORTH AMERICA (RSNA), 2021-09-01)Purpose To compare disease detection of myeloma using contemporary whole-body (WB) MRI and fluorine 18 (18F) fluorodeoxyglucose (FDG) PET/CT protocols and to correlate imaging with laboratory estimates of disease burden, ... -
Quantitative analysis of diffusion weighted imaging in rectal cancer during radiotherapy using a magnetic resonance imaging integrated linear accelerator.
Ingle, M; Blackledge, M; White, I; Wetscherek, A; Lalondrelle, S; et al. (ELSEVIER, 2022-07-01)BACKGROUND AND PURPOSE: Magnetic resonance imaging integrated linear accelerator (MR-Linac) platforms enable acquisition of diffusion weighted imaging (DWI) during treatment providing potential information about treatment ... -
Radiomic Features From Diffusion-Weighted MRI of Retroperitoneal Soft-Tissue Sarcomas Are Repeatable and Exhibit Change After Radiotherapy.
Thrussell, I; Winfield, JM; Orton, MR; Miah, AB; Zaidi, SH; et al. (FRONTIERS MEDIA SA, 2022-07-18)BACKGROUND: Size-based assessments are inaccurate indicators of tumor response in soft-tissue sarcoma (STS), motivating the requirement for new response imaging biomarkers for this rare and heterogeneous disease. In this ... -
A radiomics-based decision support tool improves lung cancer diagnosis in combination with the Herder score in large lung nodules.
Hunter, B; Chen, M; Ratnakumar, P; Alemu, E; Logan, A; et al. (ELSEVIER, 2022-12-01)BACKGROUND: Large lung nodules (≥15 mm) have the highest risk of malignancy, and may exhibit important differences in phenotypic or clinical characteristics to their smaller counterparts. Existing risk models do not stratify ... -
Radium-223 in metastatic castration-resistant prostate cancer: whole-body diffusion-weighted magnetic resonance imaging scanning to assess response.
Parker, C; Tunariu, N; Tovey, H; Alonzi, R; Blackledge, MD; et al. (OXFORD UNIV PRESS, 2023-10-31)BACKGROUND: Radium-223 is a bone-seeking, ɑ-emitting radionuclide used to treat men with bone metastases from castration-resistant prostate cancer. Sclerotic bone lesions cannot be evaluated using Response Evaluation ... -
Repeatability and reproducibility of apparent diffusion coefficient and fat fraction measurement of focal myeloma lesions on whole body magnetic resonance imaging.
Barwick, T; Orton, M; Koh, DM; Kaiser, M; Rockall, A; et al. (BRITISH INST RADIOLOGY, 2021-04-01)OBJECTIVE: To assess intra- and inter-reader variability of apparent diffusion coefficient (ADC) and fat fraction (FF) measurement in focal myeloma bone lesions and the influence of lesion size. METHODS: 22 myeloma patients ... -
Repeatability of quantitative individual lesion and total disease multiparametric whole-body MRI measurements in prostate cancer bone metastases.
Donners, R; Candito, A; Blackledge, M; Rata, M; Messiou, C; et al. (BRITISH INST RADIOLOGY, 2023-11-01)OBJECTIVES: To assess the repeatability of quantitative multiparametric whole-body MRI (mpWB-MRI) parameters in advanced prostate cancer (APC) bone metastases. METHODS: 1.5T MRI was performed twice on the same day in 10 ... -
Supervised Machine-Learning Enables Segmentation and Evaluation of Heterogeneous Post-treatment Changes in Multi-Parametric MRI of Soft-Tissue Sarcoma.
Blackledge, MD; Winfield, JM; Miah, A; Strauss, D; Thway, K; et al. (FRONTIERS MEDIA SA, 2019-10-10)Background: Multi-parametric MRI provides non-invasive methods for response assessment of soft-tissue sarcoma (STS) from non-surgical treatments. However, evaluation of MRI parameters over the whole tumor volume may not ... -
T2-adjusted computed diffusion-weighted imaging: A novel method to enhance tumour visualisation.
Cheng, L; Blackledge, MD; Collins, DJ; Orton, MR; Jerome, NP; et al. (PERGAMON-ELSEVIER SCIENCE LTD, 2016-12-01)PURPOSE: To introduce T2-adjusted computed DWI (T2-cDWI), a method that provides synthetic images at arbitrary b-values and echo times (TEs) that improve tissue contrast by removing or increasing T2 contrast in diffusion-weighted ... -
The value of baseline 18F-sodium fluoride and 18F-choline PET activity for identifying responders to radium-223 treatment in castration-resistant prostate cancer bone metastases.
Donners, R; Tunariu, N; Tovey, H; Hall, E; Chua, S; et al. (SPRINGER, 2023-08-24)OBJECTIVES: To investigate whether baseline 18F-sodium fluoride (NaF) and 18F-choline PET activity is associated with metastatic castration-resistant prostate cancer (mCRPC) global and individual bone metastases' DWI MR ... -
Virtual Biopsy in Soft Tissue Sarcoma. How Close Are We?
Arthur, A; Johnston, EW; Winfield, JM; Blackledge, MD; Jones, RL; et al. (FRONTIERS MEDIA SA, 2022-07-01)A shift in radiology to a data-driven specialty has been unlocked by synergistic developments in imaging biomarkers (IB) and computational science. This is advancing the capability to deliver "virtual biopsies" within ... -
Volume of Bone Metastasis Assessed with Whole-Body Diffusion-weighted Imaging Is Associated with Overall Survival in Metastatic Castration-resistant Prostate Cancer.
Perez-Lopez, R; Lorente, D; Blackledge, MD; Collins, DJ; Mateo, J; et al. (RADIOLOGICAL SOC NORTH AMERICA, 2016-07-01)Purpose To determine the correlation between the volume of bone metastasis as assessed with diffusion-weighted (DW) imaging and established prognostic factors in metastatic castration-resistant prostate cancer (mCRPC) and ... -
What's New for Clinical Whole-body MRI (WB-MRI) in the 21st Century.
Tunariu, N; Blackledge, M; Messiou, C; Petralia, G; Padhani, A; et al. (BRITISH INST RADIOLOGY, 2020-11-01)Whole-body MRI (WB-MRI) has evolved since its first introduction in the 1970s as an imaging technique to detect and survey disease across multiple sites and organ systems in the body. The development of diffusion-weighted ... -
Whole-body diffusion-weighted MRI in lymphoma-comparison of global apparent diffusion coefficient histogram parameters for differentiation of diseased nodes of lymphoma patients from normal lymph nodes of healthy individuals.
Donners, R; Yiin, RSZ; Koh, D-M; De Paepe, K; Chau, I; et al. (AME PUBL CO, 2021-08-01)BACKGROUND: Morphologic features yield low diagnostic accuracy to distinguish between diseased and normal lymph nodes. The purpose of this study was to compare diseased lymphomatous and normal lymph nodes using global ...