Browsing ICR Divisions by author "Parkes, Harold"
Now showing items 1-6 of 6
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Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects.
Brody, LP; Sahuri-Arisoylu, M; Parkinson, JR; Parkes, HG; So, PW; et al. (DOVE MEDICAL PRESS LTD, 2017-01-01)Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a ... -
De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.
Andrejeva, G; Gowan, S; Lin, G; Wong Te Fong, A-CL; Shamsaei, E; et al. (TAYLOR & FRANCIS INC, 2020-06)UNLABELLED: Macroautophagy/autophagy can enable cancer cells to withstand cellular stress and maintain bioenergetic homeostasis by sequestering cellular components into newly formed double-membrane vesicles destined for ... -
Determining the chemical exchange saturation transfer (CEST) behavior of citrate and spermine under in vivo conditions.
Basharat, M; deSouza, NM; Parkes, HG; Payne, GS (WILEY-BLACKWELL, 2016-09-01)PURPOSE: To estimate the exchange rates of labile (1) H in citrate and spermine, metabolites present in prostatic secretions, to predict the size of the citrate and spermine CEST effects in vivo. METHODS: CEST z-spectra ... -
Development of a temperature-controlled phantom for magnetic resonance quality assurance of diffusion, dynamic, and relaxometry measurements.
Jerome, NP; Papoutsaki, M-V; Orton, MR; Parkes, HG; Winfield, JM; et al. (WILEY, 2016-06-01)PURPOSE: Diffusion-weighted (DW) and dynamic contrast-enhanced magnetic resonance imaging (MRI) are increasingly applied for the assessment of functional tissue biomarkers for diagnosis, lesion characterization, or for ... -
Dichloroacetate induces autophagy in colorectal cancer cells and tumours.
Lin, G; Hill, DK; Andrejeva, G; Boult, JKR; Troy, H; et al. (NATURE PUBLISHING GROUP, 2014-07-15)BACKGROUND: Dichloroacetate (DCA) has been found to have antitumour properties. METHODS: We investigated the cellular and metabolic responses to DCA treatment and recovery in human colorectal (HT29, HCT116 WT and HCT116 ... -
The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells.
Delgado-Goni, T; Miniotis, MF; Wantuch, S; Parkes, HG; Marais, R; et al. (AMER ASSOC CANCER RESEARCH, 2016-12-01)Understanding the impact of BRAF signaling inhibition in human melanoma on key disease mechanisms is important for developing biomarkers of therapeutic response and combination strategies to improve long-term disease ...