Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects.
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Date
2017-01-01ICR Author
Author
Brody, LP
Sahuri-Arisoylu, M
Parkinson, JR
Parkes, HG
So, PW
Hajji, N
Thomas, EL
Frost, GS
Miller, AD
Bell, JD
Type
Journal Article
Metadata
Show full item recordAbstract
Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system - liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN). We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer. We demonstrated a substantial reduction in tumor growth in the xenograft model of colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53-/-. Nanoparticle-induced reductions in histone deacetylase gene expression indicated a potential mechanism for these anti-proliferative effects. Together, these results indicated that LITA-CAN could be used as an effective direct or adjunct therapy to treat malignant transformation in vivo.
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Subject
HCT116 Cells
HT29 Cells
Animals
Humans
Mice
Colonic Neoplasms
Cations
Acetates
Histone Deacetylases
Lipids
Antineoplastic Agents
Liposomes
Xenograft Model Antitumor Assays
Nanoparticles
Research team
Magnetic Resonance
Language
eng
License start date
2017-01
Citation
International journal of nanomedicine, 2017, 12 pp. 6677 - 6685
Publisher
DOVE MEDICAL PRESS LTD