Browsing ICR Divisions by author "Mok, Ngai"
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Applications of Systematic Molecular Scaffold Enumeration to Enrich Structure-Activity Relationship Information.
Mok, NY; Brown, N (2017-01)Establishing structure-activity relationships (SARs) in hit identification during early stage drug discovery is important in accelerating hit confirmation and expansion. We describe the development of EnCore, a systematic ... -
On the origins of three-dimensionality in drug-like molecules.
Meyers, J; Carter, M; Mok, NY; Brown, N (2016-09)Aim Many medicinal chemistry-relevant structures and core scaffolds tend toward geometric planarity, which hampers the optimization of physicochemical properties desirable in drug-like molecules. As challenging drug target ...