Browsing ICR Divisions by author "Thway, Khin"
Now showing items 1-5 of 5
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Molecular subtypes of gastrointestinal stromal tumors and their prognostic and therapeutic implications.
Szucs, Z; Thway, K; Fisher, C; Bulusu, R; Constantinidou, A; et al. (2017-01)Gastrointestinal stromal tumors (GISTs) are composed of various molecular subtypes, with differing prognostic and predictive relevance. Previously, tumors lacking mutations in the KIT and PDGFRA genes have been designated ... -
p.(L576P) -KIT mutation in GIST: Favorable prognosis and sensitive to imatinib?
Noujaim, J; Gonzalez, D; Thway, K; Jones, RL; Judson, I (2016-05)Exon 11 KIT mutations are found in a majority of gastrointestinal stromal tumors (GIST) and are usually predictive of response to imatinib, a KIT, PDGFRA and ABL inhibitor. Exon 11 mutations with poor sensitivity to imatinib ... -
Promising novel therapeutic approaches in the management of gastrointestinal stromal tumors.
Szucs, Z; Thway, K; Fisher, C; Bulusu, R; Constantinidou, A; et al. (TAYLOR & FRANCIS LTD, 2017-01-01)Primary and secondary resistance to currently available licensed tyrosine kinase inhibitors poses a real clinical challenge in the management of advanced gastrointestinal stromal tumors. Within the frame of early phase ... -
Rare Aggressive Behavior of <i>MDM2</i>-Amplified Retroperitoneal Dedifferentiated Liposarcoma, with Brain, Lung and Subcutaneous Metastases.
Ben Salha, I; Zaidi, S; Noujaim, J; Miah, AB; Fisher, C; et al. (2016-09)Dedifferentiated liposarcoma (DDL) is a histologically pleomorphic sarcoma, traditionally defined as well-differentiated liposarcoma with abrupt transition to high grade, non-lipogenic sarcoma. It can occur as part of ... -
The spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities.
Noujaim, J; Jones, RL; Swansbury, J; Gonzalez, D; Benson, C; et al. (2017-02)Background EWSR1 rearrangements were first identified in Ewing sarcoma, but the spectrum of EWSR1-rearranged neoplasms now includes many soft tissue tumour subtypes including desmoplastic small round cell tumour (DSRCT), ...