Now showing items 1-13 of 13

    • Cancer cell transmission via the placenta. 

      Greaves, M; Hughes, W (2018)
      Cancer cells have a parasitic propensity in the primary host but their capacity to transit between individuals is severely restrained by two factors: a lack of a route for viable cell transfer and immune recognition in ...
    • Carbon dating cancer: defining the chronology of metastatic progression in a colorectal cancer case 

      Lote, H; Spiteri, I; Ermini, L; Vatsiou, A; Roy, A; McDonald, A; Maka, N; Balsitis, M; Bose, N; Simbolo, M; Mafficin, A; Lampis, A; Hahne, JC; Trevisani, F; Eltahir, Z; Mentrasti, G; Findlay, C; Kalkman, EAJ; Punta, M; Werner, B; Lise, S; Aktipis, A; Maley, C; Greaves, M; Braconi, C; White, J; Fassan, M; Scarpa, A; Sottoriva, A; Valeri, N
    • Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer. 

      Lote, H; Spiteri, I; Ermini, L; Vatsiou, A; Roy, A; McDonald, A; Maka, N; Balsitis, M; Bose, N; Simbolo, M; Mafficini, A; Lampis, A; Hahne, JC; Trevisani, F; Eltahir, Z; Mentrasti, G; Findlay, C; Kalkman, EAJ; Punta, M; Werner, B; Lise, S; Aktipis, A; Maley, C; Greaves, M; Braconi, C; White, J; Fassan, M; Scarpa, A; Sottoriva, A; Valeri, N (2017-06-01)
      Background: Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs. The evolutionary trajectory of cancers can be defined using phylogenetic approaches but ...
    • Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer. 

      Lote, H; Spiteri, I; Ermini, L; Vatsiou, A; Roy, A; McDonald, A; Maka, N; Balsitis, M; Bose, N; Simbolo, M; Mafficini, A; Lampis, A; Hahne, JC; Trevisani, F; Eltahir, Z; Mentrasti, G; Findlay, C; Kalkman, EAJ; Punta, M; Werner, B; Lise, S; Aktipis, A; Maley, C; Greaves, M; Braconi, C; White, J; Fassan, M; Scarpa, A; Sottoriva, A; Valeri, N
      Background: Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs. The evolutionary trajectory of cancers can be defined using phylogenetic approaches but ...
    • Classifying the evolutionary and ecological features of neoplasms. 

      Maley, CC; Aktipis, A; Graham, TA; Sottoriva, A; Boddy, AM; Janiszewska, M; Silva, AS; Gerlinger, M; Yuan, Y; Pienta, KJ; Anderson, KS; Gatenby, R; Swanton, C; Posada, D; Wu, C-I; Schiffman, JD; Hwang, ES; Polyak, K; Anderson, ARA; Brown, JS; Greaves, M; Shibata, D (2017-10)
      Neoplasms change over time through a process of cell-level evolution, driven by genetic and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic cell determines which changes provide adaptive ...
    • A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1. 

      Vijayakrishnan, J; Kumar, R; Henrion, MY; Moorman, AV; Rachakonda, PS; Hosen, I; da Silva Filho, MI; Holroyd, A; Dobbins, SE; Koehler, R; Thomsen, H; Irving, JA; Allan, JM; Lightfoot, T; Roman, E; Kinsey, SE; Sheridan, E; Thompson, PD; Hoffmann, P; Nöthen, MM; Heilmann-Heimbach, S; Karl-Heinz, J; Greaves, M; Harrison, CJ; Bartram, CR; Schrappe, M; Stanulla, M; Hemminki, K; Houlston, RS (2016-10-03)
      Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype ...
    • Genomic Classification and Prognosis in Acute Myeloid Leukemia. 

      Papaemmanuil, E; Gerstung, M; Bullinger, L; Gaidzik, VI; Paschka, P; Roberts, ND; Potter, NE; Heuser, M; Thol, F; Bolli, N; Gundem, G; Van Loo, P; Martincorena, I; Ganly, P; Mudie, L; McLaren, S; O'Meara, S; Raine, K; Jones, DR; Teague, JW; Butler, AP; Greaves, MF; Ganser, A; Döhner, K; Schlenk, RF; Döhner, H; Campbell, PJ (2016-06)
      Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical ...
    • Human embryonic stem cells: A potential system for modeling infant leukemia harboring MLL-AF4 fusion gene 

      Greaves, M (2007)
      Infant acute lymphoblastic leukemia harboring the fusion oncogene MLL-AF4, which arises in utero during embryonic development, is characterized by its dismal prognosis and short latency. The mechanisms of transformation ...
    • Nothing in cancer makes sense except…. 

      Greaves, M (2018-02-21)
      Paraphrasing Dobzhansky's famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging picture of ...
    • Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster 

      Cazzaniga, G; Bisanti, L; Randi, G; Deandrea, S; Bungaro, S; Pregliasco, F; Perotti, D; Spreafico, F; Masera, G; Valsecchi, MG; Biondi, A; Greaves, M (Springer Science and Business Media LLC, 2017-08)
    • The silent mutational landscape of infant MLL-AF4 pro-B acute lymphoblastic leukemia. 

      Dobbins, SE; Sherborne, AL; Ma, YP; Bardini, M; Biondi, A; Cazzaniga, G; Lloyd, A; Chubb, D; Greaves, MF; Houlston, RS (2013-10)
      Over 90% of infants (< 1-year-old) diagnosed with leukemia have pro-B acute lymphoblastic leukemia (ALL) containing the MLL-AF4 fusion. When compared with other forms of paediatric ALL affecting later B-cell differentiation, ...
    • Single cell analysis of clonal architecture in acute myeloid leukaemia. 

      Potter, N; Miraki-Moud, F; Ermini, L; Titley, I; Vijayaraghavan, G; Papaemmanuil, E; Campbell, P; Gribben, J; Taussig, D; Greaves, M (2019-05)
      We used single cell Q-PCR on a micro-fluidic platform (Fluidigm) to analyse clonal, genetic architecture and phylogeny in acute myeloid leukaemia (AML) using selected mutations. Ten cases of NPM1c mutant AML were screened ...
    • The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia. 

      Furness, CL; Mansur, MB; Weston, VJ; Ermini, L; van Delft, FW; Jenkinson, S; Gale, R; Harrison, CJ; Pombo-de-Oliveira, MS; Sanchez-Martin, M; Ferrando, AA; Kearns, P; Titley, I; Ford, AM; Potter, NE; Greaves, M (2018-09)
      Single-cell genetics were used to interrogate clonal complexity and the sequence of mutational events in STIL-TAL1+ T-ALL. Single-cell multicolour FISH was used to demonstrate that the earliest detectable leukaemia subclone ...