Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
View/ Open
Date
2018-04-09ICR Author
Author
Vijayakrishnan, J
Studd, J
Broderick, P
Kinnersley, B
Holroyd, A
Law, PJ
Kumar, R
Allan, JM
Harrison, CJ
Moorman, AV
Vora, A
Roman, E
Rachakonda, S
Kinsey, SE
Sheridan, E
Thompson, PD
Irving, JA
Koehler, R
Hoffmann, P
Nöthen, MM
Heilmann-Heimbach, S
Jöckel, K-H
Easton, DF
Pharaoh, PDP
Dunning, AM
Peto, J
Canzian, F
Swerdlow, A
Eeles, RA
Kote-Jarai, Z
Muir, K
Pashayan, N
PRACTICAL Consortium,
Greaves, M
Zimmerman, M
Bartram, CR
Schrappe, M
Stanulla, M
Hemminki, K
Houlston, RS
Type
Journal Article
Metadata
Show full item recordAbstract
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
Collections
Subject
PRACTICAL Consortium
Humans
Genetic Predisposition to Disease
Glycosyltransferases
Oncogene Proteins, Fusion
HLA Antigens
Prognosis
Risk Factors
Polymorphism, Single Nucleotide
Child
Child, Preschool
Female
Male
Core Binding Factor Alpha 2 Subunit
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Genome-Wide Association Study
Research team
Aetiological Epidemiology
Cancer Genomics
Biology of Childhood Leukaemia
Myeloma Group
Oncogenetics
Language
eng
Date accepted
2018-01-25
License start date
2018-04-09
Citation
Nature communications, 2018, 9 (1), pp. 1340 - ?
Publisher
NATURE PORTFOLIO