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Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.

dc.contributor.authorVijayakrishnan, J
dc.contributor.authorStudd, J
dc.contributor.authorBroderick, P
dc.contributor.authorKinnersley, B
dc.contributor.authorHolroyd, A
dc.contributor.authorLaw, PJ
dc.contributor.authorKumar, R
dc.contributor.authorAllan, JM
dc.contributor.authorHarrison, CJ
dc.contributor.authorMoorman, AV
dc.contributor.authorVora, A
dc.contributor.authorRoman, E
dc.contributor.authorRachakonda, S
dc.contributor.authorKinsey, SE
dc.contributor.authorSheridan, E
dc.contributor.authorThompson, PD
dc.contributor.authorIrving, JA
dc.contributor.authorKoehler, R
dc.contributor.authorHoffmann, P
dc.contributor.authorNöthen, MM
dc.contributor.authorHeilmann-Heimbach, S
dc.contributor.authorJöckel, K-H
dc.contributor.authorEaston, DF
dc.contributor.authorPharaoh, PDP
dc.contributor.authorDunning, AM
dc.contributor.authorPeto, J
dc.contributor.authorCanzian, F
dc.contributor.authorSwerdlow, A
dc.contributor.authorEeles, RA
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorMuir, K
dc.contributor.authorPashayan, N
dc.contributor.authorPRACTICAL Consortium,
dc.contributor.authorGreaves, M
dc.contributor.authorZimmerman, M
dc.contributor.authorBartram, CR
dc.contributor.authorSchrappe, M
dc.contributor.authorStanulla, M
dc.contributor.authorHemminki, K
dc.contributor.authorHoulston, RS
dc.date.accessioned2018-04-04T09:49:32Z
dc.date.issued2018-04-09
dc.identifier.citationNature communications, 2018, 9 (1), pp. 1340 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1626
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-018-03178-z
dc.description.abstractGenome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
dc.formatElectronic
dc.format.extent1340 - ?
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectPRACTICAL Consortium
dc.subjectHumans
dc.subjectGenetic Predisposition to Disease
dc.subjectGlycosyltransferases
dc.subjectOncogene Proteins, Fusion
dc.subjectHLA Antigens
dc.subjectPrognosis
dc.subjectRisk Factors
dc.subjectPolymorphism, Single Nucleotide
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectMale
dc.subjectCore Binding Factor Alpha 2 Subunit
dc.subjectPrecursor B-Cell Lymphoblastic Leukemia-Lymphoma
dc.subjectGenome-Wide Association Study
dc.titleGenome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
dc.typeJournal Article
dcterms.dateAccepted2018-01-25
rioxxterms.versionofrecord10.1038/s41467-018-03178-z
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-04-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume9
pubs.embargo.termsNo embargo
icr.researchteamAetiological Epidemiology
icr.researchteamCancer Genomics
icr.researchteamBiology of Childhood Leukaemia
icr.researchteamMyeloma Group
icr.researchteamOncogenetics
dc.contributor.icrauthorVijayakrishnan, Jayaram
dc.contributor.icrauthorStudd, James
dc.contributor.icrauthorBroderick, Peter
dc.contributor.icrauthorKinnersley, Benjamin
dc.contributor.icrauthorHolroyd, Amy
dc.contributor.icrauthorLaw, Philip
dc.contributor.icrauthorSwerdlow, Anthony
dc.contributor.icrauthorEeles, Rosalind
dc.contributor.icrauthorKote-Jarai, Zsofia
dc.contributor.icrauthorGreaves, Melvyn
dc.contributor.icrauthorHoulston, Richard


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