Browsing ICR Divisions by author "Farrugia, Aaron"
Now showing items 1-3 of 3
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Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.
Farrugia, AJ; Calvo, F (Informa UK Limited, 2017-01-02)Rho family GTPases such as Cdc42 are key regulators of essential cellular processes through their effects on cytoskeletal dynamics, signaling and gene expression. Rho GTPases modulate these functions by engaging a wide ... -
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.
Calvo, F; Ranftl, R; Hooper, S; Farrugia, AJ; Moeendarbary, E; et al. (CELL PRESS, 2015-12-29)Cancer-associated fibroblasts (CAFs) are non-cancerous cells found in solid tumors that remodel the tumor matrix and promote cancer invasion and angiogenesis. Here, we demonstrate that Cdc42EP3/BORG2 is required for the ... -
The Borg family of Cdc42 effector proteins Cdc42EP1-5.
Farrugia, AJ; Calvo, F (PORTLAND PRESS LTD, 2016-12-15)Despite being discovered more than 15 years ago, the Borg (binder of Rho GTPases) family of Cdc42 effector proteins (Cdc42EP1-5) remains largely uncharacterised and relatively little is known about their structure, regulation ...