The Borg family of Cdc42 effector proteins Cdc42EP1-5.
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Date
2016-12-15ICR Author
Author
Farrugia, AJ
Calvo, F
Type
Journal Article
Metadata
Show full item recordAbstract
Despite being discovered more than 15 years ago, the Borg (binder of Rho GTPases) family of Cdc42 effector proteins (Cdc42EP1-5) remains largely uncharacterised and relatively little is known about their structure, regulation and role in development and disease. Recent studies are starting to unravel some of the key functional and mechanistic aspects of the Borg proteins, including their role in cytoskeletal remodelling and signalling. In addition, the participation of Borg proteins in important cellular processes such as cell shape, directed migration and differentiation is slowly emerging, directly linking Borgs with important physiological and pathological processes such as angiogenesis, neurotransmission and cancer-associated desmoplasia. Here, we review some of these findings and discuss future prospects.
Collections
Subject
Cytoskeleton
Humans
rho GTP-Binding Proteins
Adaptor Proteins, Signal Transducing
GTP-Binding Protein Regulators
RNA-Binding Proteins
Cytoskeletal Proteins
Signal Transduction
Multigene Family
Models, Biological
Research team
Tumour Microenvironment
Language
eng
Date accepted
2016-09-19
License start date
2016-12
Citation
Biochemical Society transactions, 2016, 44 (6), pp. 1709 - 1716
Publisher
PORTLAND PRESS LTD
Except where otherwise noted, this item's license is described
as
https://creativecommons.org/licenses/by/4.0
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