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dc.contributor.authorFarrugia, AJen_US
dc.contributor.authorCalvo, Fen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2016-11-24T14:02:04Z
dc.date.issued2016-12-15en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/27913681en_US
dc.identifierBST20160219en_US
dc.identifier.citationBiochem Soc Trans, 2016, 44 (6), pp. 1709 - 1716en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/284
dc.identifier.eissn1470-8752en_US
dc.identifier.doi10.1042/BST20160219en_US
dc.description.abstractDespite being discovered more than 15 years ago, the Borg (binder of Rho GTPases) family of Cdc42 effector proteins (Cdc42EP1-5) remains largely uncharacterised and relatively little is known about their structure, regulation and role in development and disease. Recent studies are starting to unravel some of the key functional and mechanistic aspects of the Borg proteins, including their role in cytoskeletal remodelling and signalling. In addition, the participation of Borg proteins in important cellular processes such as cell shape, directed migration and differentiation is slowly emerging, directly linking Borgs with important physiological and pathological processes such as angiogenesis, neurotransmission and cancer-associated desmoplasia. Here, we review some of these findings and discuss future prospects.en_US
dc.format.extent1709 - 1716en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectBorgen_US
dc.subjectCdc42en_US
dc.subjectRho GTPasesen_US
dc.subjectcytoskeletonen_US
dc.subjectseptinen_US
dc.subjectAdaptor Proteins, Signal Transducingen_US
dc.subjectCytoskeletonen_US
dc.subjectGTP-Binding Protein Regulatorsen_US
dc.subjectHumansen_US
dc.subjectModels, Biologicalen_US
dc.subjectMultigene Familyen_US
dc.subjectSignal Transductionen_US
dc.titleThe Borg family of Cdc42 effector proteins Cdc42EP1-5.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-09-19en_US
rioxxterms.versionofrecord10.1042/BST20160219en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2016-12-15en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBiochem Soc Transen_US
pubs.issue6en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Tumour Microenvironment
pubs.publication-statusPublisheden_US
pubs.volume44en_US
pubs.embargo.termsNot knownen_US
icr.researchteamTumour Microenvironmenten_US
dc.contributor.icrauthorCalvo, Fernandoen_US
dc.contributor.icrauthorFarrugia, Aaronen_US


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