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dc.contributor.authorFarrugia, AJ
dc.contributor.authorCalvo, F
dc.date.accessioned2016-11-24T14:02:04Z
dc.date.issued2016-12-15
dc.identifier.citationBiochemical Society transactions, 2016, 44 (6), pp. 1709 - 1716
dc.identifier.issn0300-5127
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/284
dc.identifier.eissn1470-8752
dc.identifier.doi10.1042/bst20160219
dc.description.abstractDespite being discovered more than 15 years ago, the Borg (binder of Rho GTPases) family of Cdc42 effector proteins (Cdc42EP1-5) remains largely uncharacterised and relatively little is known about their structure, regulation and role in development and disease. Recent studies are starting to unravel some of the key functional and mechanistic aspects of the Borg proteins, including their role in cytoskeletal remodelling and signalling. In addition, the participation of Borg proteins in important cellular processes such as cell shape, directed migration and differentiation is slowly emerging, directly linking Borgs with important physiological and pathological processes such as angiogenesis, neurotransmission and cancer-associated desmoplasia. Here, we review some of these findings and discuss future prospects.
dc.formatPrint
dc.format.extent1709 - 1716
dc.languageeng
dc.language.isoeng
dc.publisherPORTLAND PRESS LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectCytoskeleton
dc.subjectHumans
dc.subjectrho GTP-Binding Proteins
dc.subjectAdaptor Proteins, Signal Transducing
dc.subjectGTP-Binding Protein Regulators
dc.subjectRNA-Binding Proteins
dc.subjectCytoskeletal Proteins
dc.subjectSignal Transduction
dc.subjectMultigene Family
dc.subjectModels, Biological
dc.titleThe Borg family of Cdc42 effector proteins Cdc42EP1-5.
dc.typeJournal Article
dcterms.dateAccepted2016-09-19
rioxxterms.versionofrecord10.1042/bst20160219
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-12
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBiochemical Society transactions
pubs.issue6
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Tumour Microenvironment
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Tumour Microenvironment
pubs.publication-statusPublished
pubs.volume44
pubs.embargo.termsNot known
icr.researchteamTumour Microenvironment
dc.contributor.icrauthorFarrugia, Aaron


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