Now showing items 1-4 of 4

    • ATR Is a Therapeutic Target in Synovial Sarcoma. 

      Jones, SE; Fleuren, EDG; Frankum, J; Konde, A; Williamson, CT; Krastev, DB; Pemberton, HN; Campbell, J; Gulati, A; Elliott, R; Menon, M; Selfe, JL; Brough, R; Pettitt, SJ; Niedzwiedz, W; van der Graaf, WTA; Shipley, J; Ashworth, A; Lord, CJ (2017-12)
      Synovial sarcoma (SS) is an aggressive soft-tissue malignancy characterized by expression of SS18-SSX fusions, where treatment options are limited. To identify therapeutically actionable genetic dependencies in SS, we ...
    • EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2. 

      Nieminuszczy, J; Broderick, R; Bellani, MA; Smethurst, E; Schwab, RA; Cherdyntseva, V; Evmorfopoulou, T; Lin, Y-L; Minczuk, M; Pasero, P; Gagos, S; Seidman, MM; Niedzwiedz, W (2019-08)
      Accurate DNA replication is essential to preserve genomic integrity and prevent chromosomal instability-associated diseases including cancer. Key to this process is the cells' ability to stabilize and restart stalled ...
    • TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation. 

      Blackford, AN; Nieminuszczy, J; Schwab, RA; Galanty, Y; Jackson, SP; Niedzwiedz, W (2015-03)
      The Bloom syndrome helicase BLM and topoisomerase-IIβ-binding protein 1 (TopBP1) are key regulators of genome stability. It was recently proposed that BLM phosphorylation on Ser338 mediates its interaction with TopBP1, to ...
    • TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution. 

      Broderick, R; Nieminuszczy, J; Blackford, AN; Winczura, A; Niedzwiedz, W (2015-03-12)
      During mitosis, sister chromatids must be faithfully segregated to ensure that daughter cells receive one copy of each chromosome. However, following replication they often remain entangled. Topoisomerase IIα (TOP2A) has ...