Browsing ICR Divisions by author "Desouza, Nandita"
Now showing items 1-20 of 65
-
A data-driven statistical model that estimates measurement uncertainty improves interpretation of ADC reproducibility: a multi-site study of liver metastases.
Pathak, R; Ragheb, H; Thacker, NA; Morris, DM; Amiri, H; et al. (NATURE PORTFOLIO, 2017-10-26)Apparent Diffusion Coefficient (ADC) is a potential quantitative imaging biomarker for tumour cell density and is widely used to detect early treatment changes in cancer therapy. We propose a strategy to improve confidence ... -
A Dosimetric Comparison of Breast Radiotherapy Techniques to Treat Locoregional Lymph Nodes Including the Internal Mammary Chain.
Ranger, A; Dunlop, A; Hutchinson, K; Convery, H; Maclennan, MK; et al. (ELSEVIER SCIENCE LONDON, 2018-06-01)AIMS: Radiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses to the heart and lung should be ... -
A risk-based approach to identifying oligometastatic disease on imaging.
deSouza, NM; Tempany, CM (WILEY, 2019-02-01)Recognition of <3 metastases in <2 organs, particularly in cancers with a known predisposition to oligometastatic disease (OMD) (colorectal, prostate, renal, sarcoma and lung), offers the opportunity to focally treat the ... -
Biomarkers for site-specific response to neoadjuvant chemotherapy in epithelial ovarian cancer: relating MRI changes to tumour cell load and necrosis.
Winfield, JM; Wakefield, JC; Brenton, JD; AbdulJabbar, K; Savio, A; et al. (SPRINGERNATURE, 2021-03-16)BACKGROUND: Diffusion-weighted magnetic resonance imaging (DW-MRI) potentially interrogates site-specific response to neoadjuvant chemotherapy (NAC) in epithelial ovarian cancer (EOC). METHODS: Participants with newly ... -
Bone Metastases Are Measurable: The Role of Whole-Body MRI and Positron Emission Tomography.
Oprea-Lager, DE; Cysouw, MCF; Boellaard, R; Deroose, CM; de Geus-Oei, L-F; et al. (FRONTIERS MEDIA SA, 2021-11-19)Metastatic tumor deposits in bone marrow elicit differential bone responses that vary with the type of malignancy. This results in either sclerotic, lytic, or mixed bone lesions, which can change in morphology due to ... -
Characterisation and classification of oligometastatic disease: a European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus recommendation.
Guckenberger, M; Lievens, Y; Bouma, AB; Collette, L; Dekker, A; et al. (ELSEVIER SCIENCE INC, 2020-01-01)Oligometastatic disease has been proposed as an intermediate state between localised and systemically metastasised disease. In the absence of randomised phase 3 trials, early clinical studies show improved survival when ... -
Comparison of Imaging Changes and Pain Responses in Patients with Intra- or Extraosseous Bone Metastases Treated Palliatively with Magnetic Resonance-Guided High-Intensity-Focused Ultrasound.
Giles, SL; Brown, MRD; Rivens, I; Deppe, M; Huisman, M; et al. (ELSEVIER SCIENCE INC, 2019-02-21)PURPOSE: This study compared changes in imaging and in pain relief between patients with intraosseous, as opposed to extraosseous bone metastases. Both groups were treated palliatively with magnetic resonance-guided ... -
Comparison of optimised endovaginal vs external array coil T2-weighted and diffusion-weighted imaging techniques for detecting suspected early stage (IA/IB1) uterine cervical cancer.
Downey, K; Attygalle, AD; Morgan, VA; Giles, SL; MacDonald, A; et al. (SPRINGER, 2016-04-01)OBJECTIVE: To compare sensitivity and specificity of endovaginal versus external-array coil T2-W and T2-W + DWI for detecting and staging small cervical tumours. METHODS: Optimised endovaginal and external array coil MRI ... -
Comparison of three reference methods for the measurement of intracellular pH using 31P MRS in healthy volunteers and patients with lymphoma.
Rata, M; Giles, SL; deSouza, NM; Leach, MO; Payne, GS (WILEY-BLACKWELL, 2014-02-01)31P magnetic resonance spectroscopy (31P MRS) can measure intracellular pH (pHi) using the chemical shift difference between pH-dependent inorganic phosphate (Pi) and a pH-independent reference peak. This study compared ... -
DCE-MRI, DW-MRI, and MRS in Cancer: Challenges and Advantages of Implementing Qualitative and Quantitative Multi-parametric Imaging in the Clinic.
Winfield, JM; Payne, GS; Weller, A; deSouza, NM (Ovid Technologies (Wolters Kluwer Health), 2016-10-01)Multi-parametric magnetic resonance imaging (mpMRI) offers a unique insight into tumor biology by combining functional MRI techniques that inform on cellularity (diffusion-weighted MRI), vascular properties (dynamic ... -
Determining the chemical exchange saturation transfer (CEST) behavior of citrate and spermine under in vivo conditions.
Basharat, M; deSouza, NM; Parkes, HG; Payne, GS (WILEY-BLACKWELL, 2016-09-01)PURPOSE: To estimate the exchange rates of labile (1) H in citrate and spermine, metabolites present in prostatic secretions, to predict the size of the citrate and spermine CEST effects in vivo. METHODS: CEST z-spectra ... -
Development of a temperature-controlled phantom for magnetic resonance quality assurance of diffusion, dynamic, and relaxometry measurements.
Jerome, NP; Papoutsaki, M-V; Orton, MR; Parkes, HG; Winfield, JM; et al. (WILEY, 2016-06-01)PURPOSE: Diffusion-weighted (DW) and dynamic contrast-enhanced magnetic resonance imaging (MRI) are increasingly applied for the assessment of functional tissue biomarkers for diagnosis, lesion characterization, or for ... -
Diffusion-weighted (DW) MRI in lung cancers: ADC test-retest repeatability.
Weller, A; Papoutsaki, MV; Waterton, JC; Chiti, A; Stroobants, S; et al. (SPRINGER, 2017-11-01)PURPOSE: To determine the test-retest repeatability of Apparent Diffusion Coefficient (ADC) measurements across institutions and MRI vendors, plus investigate the effect of post-processing methodology on measurement ... -
Diffusion-Weighted Magnetic Resonance Imaging in Ovarian Cancer: Exploiting Strengths and Understanding Limitations.
Gagliardi, T; Adejolu, M; deSouza, NM (MDPI, 2022-03-10)Detection, characterization, staging, and response assessment are key steps in the imaging pathway of ovarian cancer. The most common type, high grade serous ovarian cancer, often presents late, so that accurate disease ... -
Diffusion-weighted MRI for detecting prostate tumour in men at increased genetic risk.
deSouza, NM; Morgan, VA; Bancroft, E; Sohaib, SA; Giles, SL; et al. (Elsevier BV, 2014-09-07)BACKGROUND: Diffusion-weighted (DW)-MRI is invaluable in detecting prostate cancer. We determined its sensitivity and specificity and established interobserver agreement for detecting tumour in men with a family history ... -
Diffusion-weighted MRI for imaging cell death after cytotoxic or apoptosis-inducing therapy.
Papaevangelou, E; Almeida, GS; Jamin, Y; Robinson, SP; deSouza, NM (NATURE PUBLISHING GROUP, 2015-04-28)BACKGROUND: Non-invasive serial imaging is desirable to detect processes such as necrotic and apoptotic cell death in cancer patients undergoing treatment. This study investigated the use of diffusion-weighted (DW-) magnetic ... -
Diffusion-weighted MRI in Advanced Epithelial Ovarian Cancer: Apparent Diffusion Coefficient as a Response Marker.
Winfield, JM; Wakefield, JC; Dolling, D; Hall, M; Freeman, S; et al. (2019-11)Background Treatment of advanced epithelial ovarian cancer results in a relapse rate of 75%. Early markers of response would enable optimization of management and improved outcome in both primary and recurrent disease. ... -
Distortion correction of echo-planar diffusion-weighted images of uterine cervix.
deSouza, NM; Orton, M; Downey, K; Morgan, VA; Collins, DJ; et al. (WILEY-BLACKWELL, 2016-05-01)PURPOSE: To investigate the clinical utility of the reverse gradient algorithm in correcting distortions in diffusion-weighted images of the cervix and for increasing diagnostic performance. MATERIALS AND METHODS: Forty-one ... -
Endovaginal magnetic resonance imaging of stage 1A/1B cervical cancer with A T2- and diffusion-weighted magnetic resonance technique: effect of lesion size and previous cone biopsy on tumor detectability.
Charles-Edwards, E; Morgan, V; Attygalle, AD; Giles, SL; Ind, TE; et al. (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2011-03-01)OBJECTIVE: To evaluate the effects of previous cone biopsy and lesion size on detectability of stage 1a/1b cervical cancer using endovaginal T2- and diffusion-weighted magnetic resonance imaging. METHODS: One hundred and ... -
Estimating brain volume loss after radiation therapy in children treated for posterior fossa tumors (Corpus callosum and whole brain volume changes following radiotherapy in children).
Szychot, E; Seunarine, KK; Robles, CA; Mandeville, H; Mankad, K; et al. (WROCLAW MEDICAL UNIV, 2020-03-01)BACKGROUND: More than half of pediatric tumors of central nervous system (CNS) primarily originate in the posterior fossa and are conventionally treated with radiation therapy (RT). OBJECTIVES: The objective of this study ...