Browsing ICR Divisions by author "Legrand, Arnaud"
Now showing items 1-6 of 6
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Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients.
Chen, X; Legrand, AJ; Cunniffe, S; Hume, S; Poletto, M; et al. (SPRINGER, 2018-10-01)BACKGROUND: To deliver efficacious personalised cancer treatment, it is essential to characterise the cellular metabolism as well as the genetic stability of individual tumours. In this study, we describe a new axis between ... -
Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts.
Legrand, AJ; Poletto, M; Pankova, D; Clementi, E; Moore, J; et al. (Impact Journals, LLC, 2018-03-02)Cancer-associated fibroblasts (CAFs) are an emerging target for cancer therapy as they promote tumour growth and metastatic potential. However, CAF targeting is complicated by the lack of knowledge-based strategies aiming ... -
Poly(ADP-ribose) Polyremase-1 (PARP-1) Inhibition: A Promising Therapeutic Strategy for ETS-Expressing Tumours.
Legrand, AJ; Choul-Li, S; Villeret, V; Aumercier, M (MDPI, 2023-08-30)ETS transcription factors are a highly conserved family of proteins involved in the progression of many cancers, such as breast and prostate carcinomas, Ewing's sarcoma, and leukaemias. This significant involvement can be ... -
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Liccardi, G; Ramos Garcia, L; Tenev, T; Annibaldi, A; Legrand, AJ; et al. (CELL PRESS, 2019-02-07)Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and ... -
Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage.
Fletcher, SC; Grou, CP; Legrand, AJ; Chen, X; Soderstrom, K; et al. (OXFORD UNIV PRESS, 2018-02-28)ATM (ataxia-telangiectasia mutated) is a central molecule for DNA quality control. Its activation by DNA damage promotes cell-cycle delay, which facilitates DNA repair prior to replication. On the other hand, persistent ... -
The Diversification of Cell Death and Immunity: Memento Mori.
Legrand, AJ; Konstantinou, M; Goode, EF; Meier, P (CELL PRESS, 2019-10-01)Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell ...