Browsing ICR Divisions by author "Bayliss, Richard"
Now showing items 1-2 of 2
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A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation
Richards, MW; Leung, JWC; Roe, SM; Li, K; Chen, J; et al. (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2010-02-05)Mcph1 is mutated in autosomal recessive primary microcephaly and premature chromosome condensation (PCC) syndrome. Increased chromosome condensation is a common feature of cells isolated from patients afflicted with either ... -
Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic
Dodson, CA; Bayliss, R (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012-01-06)Protein kinases are activated by phosphorylation and by the binding of activator proteins. The interplay of these two factors is incompletely understood. We applied energetic analysis to this question and characterized the ...