Browsing ICR Divisions by author "Chan Wah Hak, Charleen Min Li"
Now showing items 1-8 of 8
-
A comparison of machine learning methods for predicting recurrence and death after curative-intent radiotherapy for non-small cell lung cancer: Development and validation of multivariable clinical prediction models.
Hindocha, S; Charlton, TG; Linton-Reid, K; Hunter, B; Chan, C; et al. (ELSEVIER, 2022-03-03)BACKGROUND: Surveillance is universally recommended for non-small cell lung cancer (NSCLC) patients treated with curative-intent radiotherapy. High-quality evidence to inform optimal surveillance strategies is lacking. ... -
CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma.
Bozhanova, G; Hassan, J; Appleton, L; Jennings, V; Foo, S; et al. (BMJ PUBLISHING GROUP, 2022-03-01)BACKGROUND: Combination herpes simplex virus (HSV) oncolytic virotherapy and BRAF inhibitors (BRAFi) represent promising immunogenic treatments for BRAF mutant melanoma, but an improved understanding of the immunobiology ... -
Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy
Chan Wah Hak, CML; Rullan, A; Patin, EC; Pedersen, M; Melcher, AA; et al. (Frontiers Media SA, 2022-08-29)<jats:p>Radiotherapy is one of the most effective and frequently used treatments for a wide range of cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment the anti-tumour immune ... -
Gross tumour volume radiomics for prognostication of recurrence & death following radical radiotherapy for NSCLC.
Hindocha, S; Charlton, TG; Linton-Reid, K; Hunter, B; Chan, C; et al. (NATURE PORTFOLIO, 2022-10-27)Recurrence occurs in up to 36% of patients treated with curative-intent radiotherapy for NSCLC. Identifying patients at higher risk of recurrence for more intensive surveillance may facilitate the earlier introduction of ... -
Kickstarting Immunity in Cold Tumours: Localised Tumour Therapy Combinations With Immune Checkpoint Blockade.
Appleton, E; Hassan, J; Chan Wah Hak, C; Sivamanoharan, N; Wilkins, A; et al. (FRONTIERS MEDIA SA, 2021-10-18)Cancer patients with low or absent pre-existing anti-tumour immunity ("cold" tumours) respond poorly to treatment with immune checkpoint inhibitors (ICPI). In order to render these patients susceptible to ICPI, initiation ... -
Radiological Biomarkers in MRI directed Rectal Cancer Radiotherapy Volume Delineation.
Chan Wah Hak, C; Balyasnikova, S; Withey, S; Tait, D; Brown, G; et al. (MDPI, 2023-10-27)Our study evaluated whether an MRI reporting system highlighting areas of contiguous and discontinuous extramural venous invasion (EMVI) can improve the accuracy of gross tumour volume (GTV) delineation. Initially, 27 ... -
The National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group Workshop: Translating Novel Discoveries to and from the Clinic.
Chan Wah Hak, C; Dean, JA; Hill, MA; Somaiah, N; National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group 1(☆), (ELSEVIER SCIENCE LONDON, 2023-12-01) -
Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference.
Gregucci, F; Spada, S; Barcellos-Hoff, MH; Bhardwaj, N; Chan Wah Hak, C; et al. (TAYLOR & FRANCIS INC, 2023-12-31)Focal radiation therapy (RT) has attracted considerable attention as a combinatorial partner for immunotherapy (IT), largely reflecting a well-defined, predictable safety profile and at least some potential for immunostimulation. ...