Now showing items 1-7 of 7

    • A closed conformation of the Caenorhabditis elegans separase-securin complex. 

      Bachmann, G; Richards, MW; Winter, A; Beuron, F; Morris, E; Bayliss, R (2016-04-13)
      The protease separase plays a key role in sister chromatid disjunction and centriole disengagement. To maintain genomic stability, separase activity is strictly regulated by binding of an inhibitory protein, securin. Despite ...
    • Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. 

      Jones, M; Beuron, F; Borg, A; Nans, A; Earl, CP; Briggs, DC; Snijders, AP; Bowles, M; Morris, EP; Linch, M; McDonald, NQ (2020-02-28)
      The structure-specific endonuclease XPF-ERCC1 participates in multiple DNA damage repair pathways including nucleotide excision repair (NER) and inter-strand crosslink repair (ICLR). How XPF-ERCC1 is catalytically activated ...
    • Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA. 

      Kong, M; Cutts, EE; Pan, D; Beuron, F; Kaliyappan, T; Xue, C; Morris, EP; Musacchio, A; Vannini, A; Greene, EC (2020-05-16)
      Structural maintenance of chromosomes (SMC) complexes are essential for genome organization from bacteria to humans, but their mechanisms of action remain poorly understood. Here, we characterize human SMC complexes condensin ...
    • Nanostructures from Synthetic Genetic Polymers. 

      Taylor, AI; Beuron, F; Peak-Chew, S-Y; Morris, EP; Herdewijn, P; Holliger, P (2016-06)
      Nanoscale objects of increasing complexity can be constructed from DNA or RNA. However, the scope of potential applications could be enhanced by expanding beyond the moderate chemical diversity of natural nucleic acids. ...
    • Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome. 

      Faull, SV; Lau, AMC; Martens, C; Ahdash, Z; Hansen, K; Yebenes, H; Schmidt, C; Beuron, F; Cronin, NB; Morris, EP; Politis, A (2019-08-23)
      Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 from activated Cullins. Here we present structures ...
    • Structural basis of RNA polymerase III transcription initiation. 

      Abascal-Palacios, G; Ramsay, EP; Beuron, F; Morris, E; Vannini, A (2018-01)
      RNA polymerase (Pol) III transcribes essential non-coding RNAs, including the entire pool of transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often deregulated in cancer cells. The initiation of gene ...
    • Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling. 

      Mariotti, L; Templeton, CM; Ranes, M; Paracuellos, P; Cronin, N; Beuron, F; Morris, E; Guettler, S (2016-08)
      The poly(ADP-ribose) polymerase (PARP) Tankyrase (TNKS and TNKS2) is paramount to Wnt-β-catenin signaling and a promising therapeutic target in Wnt-dependent cancers. The pool of active β-catenin is normally limited by ...