Browsing ICR Divisions by author "Leach, Martin"
Now showing items 21-40 of 46
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Growth Trajectories, Breast Size, and Breast-Tissue Composition in a British Prebirth Cohort of Young Women.
Denholm, R; De Stavola, B; Hipwell, JH; Doran, SJ; Busana, MC; et al. (OXFORD UNIV PRESS INC, 2018-06-01)Mammographic percent density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations of magnetic resonance ... -
Imaging biomarker roadmap for cancer studies.
O'Connor, JPB; Aboagye, EO; Adams, JE; Aerts, HJWL; Barrington, SF; et al. (NATURE PORTFOLIO, 2017-03-01)Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET ... -
Inter- and Intra-Observer Repeatability of Quantitative Whole-Body, Diffusion-Weighted Imaging (WBDWI) in Metastatic Bone Disease.
Blackledge, MD; Tunariu, N; Orton, MR; Padhani, AR; Collins, DJ; et al. (PUBLIC LIBRARY SCIENCE, 2016-04-28)Quantitative whole-body diffusion-weighted MRI (WB-DWI) is now possible using semi-automatic segmentation techniques. The method enables whole-body estimates of global Apparent Diffusion Coefficient (gADC) and total Diffusion ... -
Lung volume reproducibility under ABC control and self-sustained breath-holding.
Kaza, E; Dunlop, A; Panek, R; Collins, DJ; Orton, M; et al. (WILEY, 2017-03-01)An Active Breathing Coordinator (ABC) can be employed to induce breath-holds during CT imaging and radiotherapy of lung, breast and liver cancer, and recently during lung cancer MRI. The apparatus measures and controls ... -
Magnetic Resonance Spectroscopy to Study Glycolytic Metabolism During Autophagy.
Chung, Y-L; Leach, MO; Eykyn, TR (ELSEVIER ACADEMIC PRESS INC, 2017-01-01)Cancer cells undergoing starvation- and treatment-induced autophagy were found to exhibit reduced intracellular lactate, reduced rates of steady-state lactate excretion and reduced real-time pyruvate-lactate exchange rates, ... -
Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.
Al-Saffar, NMS; Troy, H; Wong Te Fong, A-C; Paravati, R; Jackson, LE; et al. (NATURE PUBLISHING GROUP, 2018-10-30)BACKGROUND: AKT is commonly overexpressed in tumours and plays an important role in the metabolic reprogramming of cancer. We have used magnetic resonance spectroscopy (MRS) to assess whether inhibition of AKT signalling ... -
Methodological consensus on clinical proton MRS of the brain: Review and recommendations.
Wilson, M; Andronesi, O; Barker, PB; Bartha, R; Bizzi, A; et al. (WILEY, 2019-08-01)Proton MRS (1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS ... -
Microstructure Characterization of Bone Metastases from Prostate Cancer with Diffusion MRI: Preliminary Findings.
Bailey, C; Collins, DJ; Tunariu, N; Orton, MR; Morgan, VA; et al. (FRONTIERS MEDIA SA, 2018-02-16)PURPOSE: To examine the usefulness of rich diffusion protocols with high b-values and varying diffusion time for probing microstructure in bone metastases. Analysis techniques including biophysical and mathematical models ... -
Modulation of renal oxygenation and perfusion in rat kidney monitored by quantitative diffusion and blood oxygen level dependent magnetic resonance imaging on a clinical 1.5T platform.
Jerome, NP; Boult, JKR; Orton, MR; d'Arcy, J; Collins, DJ; et al. (BIOMED CENTRAL LTD, 2016-10-03)BACKGROUND: To investigate the combined use of intravoxel incoherent motion (IVIM) diffusion-weighted (DW) and blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) to assess rat renal function using a 1.5T ... -
MRI-based Assessment of 3D Intrafractional Motion of Head and Neck Cancer for Radiation Therapy.
Gurney-Champion, OJ; McQuaid, D; Dunlop, A; Wong, KH; Welsh, LC; et al. (ELSEVIER SCIENCE INC, 2018-02-01)PURPOSE: To determine the 3-dimensional (3D) intrafractional motion of head and neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS: Dynamic contrast-enhanced magnetic resonance images from 56 patients with HNSCC ... -
Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI.
Panek, R; Welsh, L; Baker, LCJ; Schmidt, MA; Wong, KH; et al. (AMER ASSOC CANCER RESEARCH, 2017-08-01)Purpose: To evaluate intrinsic susceptibility (IS) MRI for the identification of cycling hypoxia, and the assessment of its extent and spatial distribution, in head and neck squamous cell carcinoma (HNSCC) xenografts and ... -
Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy.
Agliano, A; Balarajah, G; Ciobota, DM; Sidhu, J; Clarke, PA; et al. (IMPACT JOURNALS LLC, 2017-07-18)Poor outcome for patients with glioblastomas is often associated with radioresistance. PI3K/mTOR pathway deregulation has been correlated with radioresistance; therefore, PI3K/mTOR inhibition could render tumors radiosensitive. ... -
Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review.
Denholm, R; De Stavola, B; Hipwell, JH; Doran, SJ; Busana, MC; et al. (BMC, 2016-10-12)BACKGROUND: Breast density, the amount of fibroglandular tissue in the adult breast for a women's age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, ... -
Prospective, longitudinal, multi-modal functional imaging for radical chemo-IMRT treatment of locally advanced head and neck cancer: the INSIGHT study.
Welsh, L; Panek, R; McQuaid, D; Dunlop, A; Schmidt, M; et al. (BIOMED CENTRAL LTD, 2015-05-15)BACKGROUND: Radical chemo-radiotherapy (CRT) is an effective organ-sparing treatment option for patients with locally advanced head and neck cancer (LAHNC). Despite advances in treatment for LAHNC, a significant minority ... -
Repeatability and sensitivity of T2* measurements in patients with head and neck squamous cell carcinoma at 3T.
Panek, R; Welsh, L; Dunlop, A; Wong, KH; Riddell, AM; et al. (WILEY-BLACKWELL, 2016-07-01)PURPOSE: To determine whether quantitation of T2* is sufficiently repeatable and sensitive to detect clinically relevant oxygenation levels in head and neck squamous cell carcinoma (HNSCC) at 3T. MATERIALS AND METHODS: Ten ... -
Repeatability of derived parameters from histograms following non-Gaussian diffusion modelling of diffusion-weighted imaging in a paediatric oncological cohort.
Jerome, NP; Miyazaki, K; Collins, DJ; Orton, MR; d'Arcy, JA; et al. (SPRINGER, 2017-01-01)OBJECTIVES: To examine repeatability of parameters derived from non-Gaussian diffusion models in data acquired in children with solid tumours. METHODS: Paediatric patients (<16 years, n = 17) were scanned twice, 24 h apart, ... -
Slice Encoding for Metal Artefact Correction in magnetic resonance imaging examinations for radiotherapy planning.
Schmidt, MA; Panek, R; Colgan, R; Hughes, J; Sohaib, A; et al. (ELSEVIER IRELAND LTD, 2016-08-01)BACKGROUND AND PURPOSE: Magnetic resonance (MR) and computed tomography (CT) images are degraded in the presence of metallic implants. We investigate whether SEMAC (Slice Encoding for Metal Artifact Correction) MR is ... -
Super-resolution T2-weighted 4D MRI for image guided radiotherapy.
Freedman, JN; Collins, DJ; Gurney-Champion, OJ; McClelland, JR; Nill, S; et al. (ELSEVIER IRELAND LTD, 2018-12-01)BACKGROUND AND PURPOSE: The superior soft-tissue contrast of 4D-T2w MRI motivates its use for delineation in radiotherapy treatment planning. We address current limitations of slice-selective implementations, including ... -
Synthetic 4D-CT of the thorax for treatment plan adaptation on MR-guided radiotherapy systems.
Freedman, JN; Bainbridge, HE; Nill, S; Collins, DJ; Kachelrieß, M; et al. (IOP PUBLISHING LTD, 2019-05-23)MR-guided radiotherapy treatment planning utilises the high soft-tissue contrast of MRI to reduce uncertainty in delineation of the target and organs at risk. Replacing 4D-CT with MRI-derived synthetic 4D-CT would support ... -
T2-adjusted computed diffusion-weighted imaging: A novel method to enhance tumour visualisation.
Cheng, L; Blackledge, MD; Collins, DJ; Orton, MR; Jerome, NP; et al. (PERGAMON-ELSEVIER SCIENCE LTD, 2016-12-01)PURPOSE: To introduce T2-adjusted computed DWI (T2-cDWI), a method that provides synthetic images at arbitrary b-values and echo times (TEs) that improve tissue contrast by removing or increasing T2 contrast in diffusion-weighted ...