Repeatability and sensitivity of T2* measurements in patients with head and neck squamous cell carcinoma at 3T.
View/ Open
Date
2016-07-01Author
Panek, R
Welsh, L
Dunlop, A
Wong, KH
Riddell, AM
Koh, D-M
Schmidt, MA
Doran, S
Mcquaid, D
Hopkinson, G
Richardson, C
Nutting, CM
Bhide, SA
Harrington, KJ
Robinson, SP
Newbold, KL
Leach, MO
Type
Journal Article
Metadata
Show full item recordAbstract
PURPOSE: To determine whether quantitation of T2* is sufficiently repeatable and sensitive to detect clinically relevant oxygenation levels in head and neck squamous cell carcinoma (HNSCC) at 3T. MATERIALS AND METHODS: Ten patients with newly diagnosed locally advanced HNSCC underwent two magnetic resonance imaging (MRI) scans between 24 and 168 hours apart prior to chemoradiotherapy treatment. A multiple gradient echo sequence was used to calculate T2* maps. A quadratic function was used to model the blood transverse relaxation rate as a function of blood oxygenation. A set of published coefficients measured at 3T were incorporated to account for tissue hematocrit levels and used to plot the dependence of fractional blood oxygenation (Y) on T2* values, together with the corresponding repeatability range. Repeatability of T2* using Bland-Altman analysis, and calculation of limits of agreement (LoA), was used to assess the sensitivity, defined as the minimum difference in fractional blood oxygenation that can be confidently detected. RESULTS: T2* LoA for 22 outlined tumor volumes were 13%. The T2* dependence of fractional blood oxygenation increases monotonically, resulting in increasing sensitivity of the method with increasing blood oxygenation. For fractional blood oxygenation values above 0.11, changes in T2* were sufficient to detect differences in blood oxygenation greater than 10% (Δ T2* > LoA for ΔY > 0.1). CONCLUSION: Quantitation of T2* at 3T can detect clinically relevant changes in tumor oxygenation within a wide range of blood volumes and oxygen tensions, including levels reported in HNSCC. J. Magn. Reson. Imaging 2016;44:72-80.
Collections
Subject
Humans
Carcinoma, Squamous Cell
Head and Neck Neoplasms
Oxygen
Image Interpretation, Computer-Assisted
Observer Variation
Magnetic Resonance Imaging
Sensitivity and Specificity
Reproducibility of Results
Middle Aged
Female
Male
Biomarkers, Tumor
Squamous Cell Carcinoma of Head and Neck
Research team
Magnetic Resonance
Pre-Clinical MRI
Targeted Therapy
Language
eng
Date accepted
2015-12-02
License start date
2016-07
Citation
Journal of magnetic resonance imaging : JMRI, 2016, 44 (1), pp. 72 - 80
Publisher
WILEY-BLACKWELL