dc.contributor.author | Panek, R | |
dc.contributor.author | Welsh, L | |
dc.contributor.author | Dunlop, A | |
dc.contributor.author | Wong, KH | |
dc.contributor.author | Riddell, AM | |
dc.contributor.author | Koh, D-M | |
dc.contributor.author | Schmidt, MA | |
dc.contributor.author | Doran, S | |
dc.contributor.author | Mcquaid, D | |
dc.contributor.author | Hopkinson, G | |
dc.contributor.author | Richardson, C | |
dc.contributor.author | Nutting, CM | |
dc.contributor.author | Bhide, SA | |
dc.contributor.author | Harrington, KJ | |
dc.contributor.author | Robinson, SP | |
dc.contributor.author | Newbold, KL | |
dc.contributor.author | Leach, MO | |
dc.date.accessioned | 2020-06-22T15:47:20Z | |
dc.date.issued | 2016-07-01 | |
dc.identifier.citation | Journal of magnetic resonance imaging : JMRI, 2016, 44 (1), pp. 72 - 80 | |
dc.identifier.issn | 1053-1807 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3763 | |
dc.identifier.eissn | 1522-2586 | |
dc.identifier.doi | 10.1002/jmri.25134 | |
dc.description.abstract | PURPOSE: To determine whether quantitation of T2* is sufficiently repeatable and sensitive to detect clinically relevant oxygenation levels in head and neck squamous cell carcinoma (HNSCC) at 3T. MATERIALS AND METHODS: Ten patients with newly diagnosed locally advanced HNSCC underwent two magnetic resonance imaging (MRI) scans between 24 and 168 hours apart prior to chemoradiotherapy treatment. A multiple gradient echo sequence was used to calculate T2* maps. A quadratic function was used to model the blood transverse relaxation rate as a function of blood oxygenation. A set of published coefficients measured at 3T were incorporated to account for tissue hematocrit levels and used to plot the dependence of fractional blood oxygenation (Y) on T2* values, together with the corresponding repeatability range. Repeatability of T2* using Bland-Altman analysis, and calculation of limits of agreement (LoA), was used to assess the sensitivity, defined as the minimum difference in fractional blood oxygenation that can be confidently detected. RESULTS: T2* LoA for 22 outlined tumor volumes were 13%. The T2* dependence of fractional blood oxygenation increases monotonically, resulting in increasing sensitivity of the method with increasing blood oxygenation. For fractional blood oxygenation values above 0.11, changes in T2* were sufficient to detect differences in blood oxygenation greater than 10% (Δ T2* > LoA for ΔY > 0.1). CONCLUSION: Quantitation of T2* at 3T can detect clinically relevant changes in tumor oxygenation within a wide range of blood volumes and oxygen tensions, including levels reported in HNSCC. J. Magn. Reson. Imaging 2016;44:72-80. | |
dc.format | Print-Electronic | |
dc.format.extent | 72 - 80 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY-BLACKWELL | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Carcinoma, Squamous Cell | |
dc.subject | Head and Neck Neoplasms | |
dc.subject | Oxygen | |
dc.subject | Image Interpretation, Computer-Assisted | |
dc.subject | Observer Variation | |
dc.subject | Magnetic Resonance Imaging | |
dc.subject | Sensitivity and Specificity | |
dc.subject | Reproducibility of Results | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Biomarkers, Tumor | |
dc.subject | Squamous Cell Carcinoma of Head and Neck | |
dc.title | Repeatability and sensitivity of T2* measurements in patients with head and neck squamous cell carcinoma at 3T. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2015-12-02 | |
rioxxterms.versionofrecord | 10.1002/jmri.25134 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Journal of magnetic resonance imaging : JMRI | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 44 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Magnetic Resonance | |
icr.researchteam | Pre-Clinical MRI | |
icr.researchteam | Targeted Therapy | |
dc.contributor.icrauthor | Doran, Simon | |
dc.contributor.icrauthor | Harrington, Kevin | |
dc.contributor.icrauthor | Robinson, Simon | |
dc.contributor.icrauthor | Leach, Martin | |