Browsing ICR Divisions by author "Davey, Norman"
Now showing items 21-25 of 25
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Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.
Wigington, CP; Roy, J; Damle, NP; Yadav, VK; Blikstad, C; et al. (CELL PRESS, 2020-07-16)Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify. We harnessed unbiased systematic approaches ... -
The articles.ELM resource: simplifying access to protein linear motif literature by annotation, text-mining and classification.
Palopoli, N; Iserte, JA; Chemes, LB; Marino-Buslje, C; Parisi, G; et al. (OXFORD UNIV PRESS, 2020-01-01)Modern biology produces data at a staggering rate. Yet, much of these biological data is still isolated in the text, figures, tables and supplementary materials of articles. As a result, biological information created at ... -
The Eukaryotic Linear Motif resource: 2022 release.
Kumar, M; Michael, S; Alvarado-Valverde, J; Mészáros, B; Sámano-Sánchez, H; et al. (OXFORD UNIV PRESS, 2022-01-07)Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource remains an invaluable source of information for the study of motif-mediated protein-protein interactions. ELM provides a comprehensive, ... -
The functional importance of structure in unstructured protein regions.
Davey, NE (CURRENT BIOLOGY LTD, 2019-06-01)After two decades of research, intrinsically disordered regions (IDRs) are established as a widespread phenomenon. The growing understanding of the significant functional role of IDRs has challenged the structure-function ... -
The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.
Di Fiore, B; Wurzenberger, C; Davey, NE; Pines, J (CELL PRESS, 2016-12-15)The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex ...