Browsing ICR Divisions by author "Behrens, Axel"
Now showing items 21-25 of 25
-
Tissue architecture in tumor initiation and progression.
Almagro, J; Messal, HA; Elosegui-Artola, A; van Rheenen, J; Behrens, A (CELL PRESS, 2022-06-01)The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the ... -
Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Messal, HA; Alt, S; Ferreira, RMM; Gribben, C; Wang, VM-Y; et al. (NATURE PUBLISHING GROUP, 2019-02-07)Tubular epithelia are a basic building block of organs and a common site of cancer occurrence1-4. During tumorigenesis, transformed cells overproliferate and epithelial architecture is disrupted. However, the biophysical ... -
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer.
Nelson, JK; Thin, MZ; Evan, T; Howell, S; Wu, M; et al. (NATURE PORTFOLIO, 2022-04-19)Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and represent an emerging therapeutic paradigm in cancer. However, their therapeutic potential in pancreatic ductal adenocarcinoma ... -
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
Ruiz, EJ; Pinto-Fernandez, A; Turnbull, AP; Lan, L; Charlton, TM; et al. (eLIFE SCIENCES PUBL LTD, 2021-10-12)Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient's 5-year survival rate is less than 5%. The ... -
USP7 controls NGN3 stability and pancreatic endocrine lineage development.
Manea, T; Nelson, JK; Garrone, CM; Hansson, K; Evans, I; et al. (NATURE PORTFOLIO, 2023-04-28)Understanding the factors and mechanisms involved in beta-cell development will guide therapeutic efforts to generate fully functional beta cells for diabetes. Neurogenin 3 (NGN3) is the key transcription factor that marks ...