Tissue architecture in tumor initiation and progression.
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Date
2022-06-01ICR Author
Author
Almagro, J
Messal, HA
Elosegui-Artola, A
van Rheenen, J
Behrens, A
Type
Journal Article
Metadata
Show full item recordAbstract
The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissue, and the molecular and cellular microenvironment modulate the morphology of the tumor and its malignant potential through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have investigated how tissue architecture influences cancer biology from tumor initiation and progression to distant metastatic seeding and response to therapy. With a focus on carcinoma, the most common type of cancer, this review discusses the latest discoveries on how tumor architecture is built and how tissue morphology affects the biology and progression of cancer cells.
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Subject
Stromal Cells
Humans
Neoplasms
Cell Transformation, Neoplastic
Tumor Microenvironment
Language
eng
Date accepted
2022-02-17
Citation
Trends in cancer, 2022, 8 (6), pp. 494 - 505
Publisher
CELL PRESS