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dc.contributor.authorAlmagro, J
dc.contributor.authorMessal, HA
dc.contributor.authorElosegui-Artola, A
dc.contributor.authorvan Rheenen, J
dc.contributor.authorBehrens, A
dc.date.accessioned2022-05-27T10:54:07Z
dc.date.available2022-05-27T10:54:07Z
dc.identifier.citationTrends in cancer, 2022, 8 (6), pp. 494 - 505en
dc.identifier.issn2405-8033
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5158
dc.identifier.eissn2405-8025en_US
dc.identifier.eissn2405-8025
dc.identifier.doi10.1016/j.trecan.2022.02.007en_US
dc.identifier.doi10.1016/j.trecan.2022.02.007
dc.description.abstractThe 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissue, and the molecular and cellular microenvironment modulate the morphology of the tumor and its malignant potential through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have investigated how tissue architecture influences cancer biology from tumor initiation and progression to distant metastatic seeding and response to therapy. With a focus on carcinoma, the most common type of cancer, this review discusses the latest discoveries on how tumor architecture is built and how tissue morphology affects the biology and progression of cancer cells.en_US
dc.formatPrint-Electronicen_US
dc.format.extent494 - 505en_US
dc.languageengen_US
dc.language.isoengen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectStromal Cellsen_US
dc.subjectHumansen_US
dc.subjectNeoplasmsen_US
dc.subjectCell Transformation, Neoplasticen_US
dc.subjectTumor Microenvironmenten_US
dc.titleTissue architecture in tumor initiation and progression.en
dc.typeJournal Article
dcterms.dateAccepted2022-02-17
rioxxterms.versionVoRen
rioxxterms.versionofrecord10.1016/j.trecan.2022.02.007en
dc.relation.isPartOfTrends in canceren_US
pubs.issue6en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.publication-statusAccepteden_US
pubs.volume8en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorBehrens, Axelen_US


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