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Redox requirements for ubiquitin-like urmylation of Ahp1, a 2-Cys peroxiredoxin from yeast.
(ELSEVIER, 2020-02-01)
The yeast peroxiredoxin Ahp1, like related anti-oxidant enzymes in other species, undergoes urmylation, a lysine-directed conjugation to ubiquitin-like modifier Urm1. Ahp1 assembles into a homodimer that detoxifies peroxides ...
Brigatinib Versus Crizotinib in Advanced ALK Inhibitor-Naive ALK-Positive Non-Small Cell Lung Cancer: Second Interim Analysis of the Phase III ALTA-1L Trial.
(AMER SOC CLINICAL ONCOLOGY, 2020-11-01)
PURPOSE: Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, demonstrated superior progression-free survival (PFS) and improved health-related quality of life (QoL) versus crizotinib in advanced ALK ...
IPEM topical report: current molecular radiotherapy service provision and guidance on the implications of setting up a dosimetry service.
(IOP Publishing Ltd, 2020-12-22)
Despite a growth in molecular radiotherapy treatment (MRT) and an increase in interest, centres still rarely perform MRT dosimetry. The aims of this report were to assess the main reasons why centres are not performing MRT ...
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.
(NATURE PORTFOLIO, 2020-11-09)
To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed genomic analysis of mouse tongue lesions. The mutational ...
Ending 40 years of silence: Rationale for a new staging system for soft tissue sarcoma of the head and neck.
(ELSEVIER IRELAND LTD, 2019-02-01)
The tumor, node, metastases (TNM) anatomic staging system plays a pivotal role in cancer care, research, and cancer control activities. Since the first edition of the American Joint Committee on Cancer TNM staging ...
How we treat neurological toxicity from immune checkpoint inhibitors.
(ELSEVIER, 2019-07-01)
Neurological adverse events from immune checkpoint inhibition are increasingly recognised, especially with combination anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) and anti-programmed death receptor 1 (anti-PD-1) therapies. ...
Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading.
(AMER ASSOC ADVANCEMENT SCIENCE, 2017-07-21)
Bidirectional replication from eukaryotic DNA replication origins requires the loading of two ring-shaped minichromosome maintenance (MCM) helicases around DNA in opposite orientations. MCM loading is orchestrated by binding ...
Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients.
(ELSEVIER SCI LTD, 2020-12-01)
PURPOSE: No studies extensively compared the young adults (YA, 18-39 years), middle-aged (40-69 years), and elderly (≥70 years) population with primary high-grade extremity soft tissue sarcoma (eSTS). This study aimed to ...
Tracheo-oesophageal fistula: a delayed complication of missed inhaled magnetic toys.
(OXFORD UNIV PRESS, 2018-02-01)
Delayed diagnosis of tracheobronchial foreign body (FB) aspiration is not uncommon in children. It occurs when symptoms are underappreciated and/or radiological findings are overlooked. In such cases serious complications ...
Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth.
(AMER PHYSIOLOGICAL SOC, 2012-10-15)
In autosomal dominant polycystic kidney disease (ADPKD), cystic fibrosis transmembrane conductance regulator (CFTR), the protein product of the gene defective in cystic fibrosis (CF), plays a crucial role in fluid accumulation, ...