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Now showing items 4351-4360 of 4435
Mixed Reality Platforms in Telehealth Delivery: Scoping Review.
(JMIR Publications Inc., 2023-03-24)
BACKGROUND: The distinctive features of the digital reality platforms, namely augmented reality (AR), virtual reality (VR), and mixed reality (MR) have extended to medical education, training, simulation, and patient care. ...
Genomic evolution shapes prostate cancer disease type.
(ELSEVIER, 2024-03-13)
The development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling tumor cells to rapidly proliferate and eventually invade ...
A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
(ELSEVIER SCI LTD, 2024-05-26)
INTRODUCTION: There is a need to improve the outcomes of patients with head and neck squamous cell carcinoma (HNSCC) and nasopharyngeal carcinoma (NPC), especially in recurrent unresectable and metastatic (R/M) setting. ...
BRCA awareness and testing experience in the UK Jewish population: a qualitative study.
(BMJ PUBLISHING GROUP, 2024-06-20)
BACKGROUND: 1 in 40 UK Jewish individuals carry a pathogenic variant in BRCA1/BRCA2. Traditional testing criteria miss half of carriers, and so population genetic testing is being piloted for Jewish people in England. There ...
DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells.
(CELL PRESS, 2024-01-19)
To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The mechanisms by which intracellular ...
Promising novel therapeutic approaches in the management of gastrointestinal stromal tumors.
(TAYLOR & FRANCIS LTD, 2017-01-01)
Primary and secondary resistance to currently available licensed tyrosine kinase inhibitors poses a real clinical challenge in the management of advanced gastrointestinal stromal tumors. Within the frame of early phase ...
A Mitsunobu reaction to functionalized cyclic and bicyclic <i>N</i>-arylamines
(PERGAMON-ELSEVIER SCIENCE LTD, 2018-01-17)
The scope of an unexpected Mitsunobu cyclisation to prepare N-arylated Fsp3-enriched azacycles was investigated. In the current study, we have identified whether a pKa-dependent Mitsunobu cyclodehydration or a pKa-independent ...
Phenotypic noise and plasticity in cancer evolution.
(CELL PRESS, 2023-11-13)
Non-genetic alterations can produce changes in a cell's phenotype. In cancer, these phenomena can influence a cell's fitness by conferring access to heritable, beneficial phenotypes. Herein, we argue that current discussions ...
Acceleration-Based Kalman Tracking for Super-Resolution Ultrasound Imaging In Vivo
(IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2023-12-01)
Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology.
(NATURE PORTFOLIO, 2024-06-18)
Tumor genomic profiling is increasingly seen as a prerequisite to guide the treatment of patients with cancer. To explore the value of whole-genome sequencing (WGS) in broadening the scope of cancers potentially amenable ...