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Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
(2001-04-24)
The telomerase enzyme is a potential therapeutic target in many human cancers. A series of potent inhibitors has been designed by computer modeling, which exploit the unique structural features of quadruplex DNA, These ...
Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands
(2001-05-01)
Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands. We have used DNase I footprinting to examine the interaction of several tripler-binding ligands with antiparallel TG- and AG- ...