Browsing Closed Research Teams by author "Marais, Richard Malcolm"
Now showing items 1-2 of 2
-
Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma
Smith, MP; Ferguson, J; Arozarena, I; Hayward, R; Marais, R; et al. (OXFORD UNIV PRESS INC, 2013-01-01)The mitogen-activated proteinkinase pathway consisting of the kinases RAF, MEK, and ERK is central to cell proliferation and survival and is deregulated in more than 90% of melanomas. MEK inhibitors are currently trialled ... -
The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNF alpha
Smith, MP; Sanchez-Laorden, B; O Brien, K; Brunton, H; Ferguson, J; et al. (AMER ASSOC CANCER RESEARCH, 2014-10-01)Recently, the rationale for combining targeted therapy with immunotherapy has come to light, but our understanding of the immune response during MAPK pathway inhibitor treatment is limited. We discovered that the immune ...