Browsing Closed Research Teams by author "Au, Lewis"
Now showing items 1-3 of 3
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Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal.
Turajlic, S; Xu, H; Litchfield, K; Rowan, A; Horswell, S; et al. (CELL PRESS, 2018-04-19)The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, ... -
Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study.
Fu, X; Zhao, Y; Lopez, JI; Rowan, A; Au, L; et al. (NATURE PORTFOLIO, 2022-01-01)Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant clonal dynamics remain limited. We investigated spatial and temporal features of clonal diversification in clear cell ... -
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.
Turajlic, S; Xu, H; Litchfield, K; Rowan, A; Chambers, T; et al. (CELL PRESS, 2018-04-19)Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with ...