Browsing Closed Research Teams by author "Shamsaei, Elham"
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Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents.
Tietz, O; Kamaly, N; Smith, G; Shamsaei, E; Bhakoo, KK; et al. (2013-01-01)The G-protein coupled C-X-C chemokine receptor type 4 (CXCR4) is highly overexpressed in a range of cancers and is therefore an excellent biomarker for cancer imaging. To this end targeted iron oxide nanoparticles were ... -
Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells.
Curry, E; Green, I; Chapman-Rothe, N; Shamsaei, E; Kandil, S; et al. (BMC, 2015-08-21)BACKGROUND: Many cancers show aberrant silencing of gene expression and overexpression of histone methyltransferases. The histone methyltransferases (HKMT) EZH2 and EHMT2 maintain the repressive chromatin histone methylation ...