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PTEN inactivation has distinct effects on the signalling properties of EGFR and MET and their response to kinase inhibitors
(Institute of Cancer Research (University Of London), 2020-09-30)
Receptor tyrosine kinases (RTKs) are a family of cell-surface receptors that play a major role in regulating pro-proliferative and pro-survival signalling pathways, such as the Phosphoinositide 3-kinase (PI3K/Akt) pathway. ...