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FDG-PET/CT Limited to the Thorax and Upper Abdomen for Staging and Management of Lung Cancer.

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Publication Date
2016-01
ICR Author
Oyen, Willem
Author
Arens, AIJ
Postema, JWA
Schreurs, WMJ
Lafeber, A
Hendrickx, BW
Oyen, WJG
Vogel, WV
Type
Journal Article
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Abstract
<h4>Purpose</h4>This study evaluates the diagnostic accuracy of [F-18]-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) of the chest/upper abdomen compared to the generally performed scan from head to upper thighs, for staging and management of (suspected) lung cancer in patients with no history of malignancy or complaints outside the thorax.<h4>Methods</h4>FDG-PET/CT scans of 1059 patients with suspected or recently proven lung cancer, with no history of malignancy or complaints outside the thorax, were analysed in a retrospective multi-centre trial. Suspect FDG-avid lesions in the chest and upper abdomen, the head and neck area above the shoulder line and in the abdomen and pelvis below the caudal tip of the liver were noted. The impact of lesions detected in the head and neck area and abdomen and pelvis on additional diagnostic procedures, staging and treatment decisions was evaluated.<h4>Results</h4>The head and neck area revealed additional suspect lesions in 7.2%, and the abdomen and pelvis in 15.8% of patients. Imaging of the head and neck area and the abdomen and pelvic area showed additional lesions in 19.5%, inducing additional diagnostic procedures in 7.8%. This resulted in discovery of additional lesions considered malignant in 10.7%, changing patient management for lung cancer in 1.2%. In (suspected) lung cancer, PET/CT limited to the chest and upper abdomen resulted in correct staging in 98.7% of patients, which led to the identical management as full field of view PET in 98.8% of patients.<h4>Conclusion</h4>High value of FDG-PET/CT for staging and correct patient management is already achieved with chest and upper abdomen. Findings in head and neck area and abdomen and pelvis generally induce investigations with limited or no impact on staging and treatment of NSCLC, and can be interpreted accordingly.
URL
https://repository.icr.ac.uk/handle/internal/102
Collections
  • Radiotherapy and Imaging
Licenseref URL
https://creativecommons.org/licenses/by/4.0
Version of record
10.1371/journal.pone.0160539
Subject
Abdomen
Pelvis
Thorax
Humans
Lung Neoplasms
Fluorodeoxyglucose F18
Neoplasm Staging
Image Processing, Computer-Assisted
Adult
Aged
Aged, 80 and over
Middle Aged
Disease Management
Female
Male
Positron Emission Tomography Computed Tomography
Research team
Translational Molecular Imaging
Language
eng
Date accepted
2016-07-21
License start date
2016-01
Citation
PloS one, 2016, 11 (8), pp. e0160539 - ?

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