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18F-FDG PET/CT in Local Ablative Therapies: A Systematic Review.

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Date
2018-04
ICR Author
Oyen, Willem
Author
Aarntzen, EHJG
Heijmen, L
Oyen, WJG
Type
Journal Article
Metadata
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Abstract
Driven by the continuous improvement in the accuracy of cross-sectional imaging, image-guided minimally invasive local ablative therapies have received incremental interest over the past few years. In this article, we systematically review the currently available literature on 18F-FDG PET/CT to monitor the efficacy of these local ablative therapies. By including all local ablative treatment modalities, tumor types, and organ sites, we provide a comprehensive overview of the current status, identify general patterns across studies, and provide recommendations for future studies and clinical practice. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS) criteria were used to assess the quality of the reported diagnostic accuracy of the retrieved studies. Data in the literature suggest that 18F-FDG PET/CT is a highly accurate tool to assess the technical success of local treatment, to identify residual or recurrent tumor early after intervention, and to provide prognostic and predictive information. However, prospective interventional studies based on 18F-FDG PET/CT findings of disease activity are mandatory to develop uniform and quantitative criteria for PET evaluation. Moreover, the optimal timing of 18F-FDG PET/CT after treatment may vary according to the location of the disease, with very early imaging being possible in solid organs such as the liver but posttreatment imaging being challenging for 3 mo in a location such as the lung parenchyma.
URI
https://repository.icr.ac.uk/handle/internal/1036
DOI
https://doi.org/10.2967/jnumed.117.198184
Collections
  • Radiotherapy and Imaging
Subject
Humans
Neoplasms
Fluorodeoxyglucose F18
Treatment Outcome
Ablation Techniques
Positron Emission Tomography Computed Tomography
Research team
Translational Molecular Imaging
Language
eng
Date accepted
2017-12-13
License start date
2018-04
Citation
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018, 59 (4), pp. 551 - 556

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