Magnetic Resonance Imaging-Guided Adaptive Radiation Therapy: A "Game Changer" for Prostate Treatment?
van As, NJ
van der Heide, UA
van Herk, M
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Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.
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Magnetic Resonance Imaging
Radiotherapy Planning, Computer-Assisted
Dose Fractionation, Radiation
Radiotherapy Physics Modelling
Stereotactic and Precision Body Radiotherapy
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International journal of radiation oncology, biology, physics, 2018, 100 (2), pp. 361 - 373