dc.contributor.author | Jarvis, D | |
dc.contributor.author | Mitchell, JS | |
dc.contributor.author | Law, PJ | |
dc.contributor.author | Palin, K | |
dc.contributor.author | Tuupanen, S | |
dc.contributor.author | Gylfe, A | |
dc.contributor.author | Hänninen, UA | |
dc.contributor.author | Cajuso, T | |
dc.contributor.author | Tanskanen, T | |
dc.contributor.author | Kondelin, J | |
dc.contributor.author | Kaasinen, E | |
dc.contributor.author | Sarin, A-P | |
dc.contributor.author | Kaprio, J | |
dc.contributor.author | Eriksson, JG | |
dc.contributor.author | Rissanen, H | |
dc.contributor.author | Knekt, P | |
dc.contributor.author | Pukkala, E | |
dc.contributor.author | Jousilahti, P | |
dc.contributor.author | Salomaa, V | |
dc.contributor.author | Ripatti, S | |
dc.contributor.author | Palotie, A | |
dc.contributor.author | Järvinen, H | |
dc.contributor.author | Renkonen-Sinisalo, L | |
dc.contributor.author | Lepistö, A | |
dc.contributor.author | Böhm, J | |
dc.contributor.author | Meklin, J-P | |
dc.contributor.author | Al-Tassan, NA | |
dc.contributor.author | Palles, C | |
dc.contributor.author | Martin, L | |
dc.contributor.author | Barclay, E | |
dc.contributor.author | Farrington, SM | |
dc.contributor.author | Timofeeva, MN | |
dc.contributor.author | Meyer, BF | |
dc.contributor.author | Wakil, SM | |
dc.contributor.author | Campbell, H | |
dc.contributor.author | Smith, CG | |
dc.contributor.author | Idziaszczyk, S | |
dc.contributor.author | Maughan, TS | |
dc.contributor.author | Kaplan, R | |
dc.contributor.author | Kerr, R | |
dc.contributor.author | Kerr, D | |
dc.contributor.author | Buchanan, DD | |
dc.contributor.author | Win, AK | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Jenkins, MA | |
dc.contributor.author | Lindor, NM | |
dc.contributor.author | Newcomb, PA | |
dc.contributor.author | Gallinger, S | |
dc.contributor.author | Conti, D | |
dc.contributor.author | Schumacher, F | |
dc.contributor.author | Casey, G | |
dc.contributor.author | Taipale, J | |
dc.contributor.author | Aaltonen, LA | |
dc.contributor.author | Cheadle, JP | |
dc.contributor.author | Dunlop, MG | |
dc.contributor.author | Tomlinson, IP | |
dc.contributor.author | Houlston, RS | |
dc.date.accessioned | 2016-09-21T09:49:14Z | |
dc.date.issued | 2016-07-12 | |
dc.identifier.citation | British journal of cancer, 2016, 115 (2), pp. 266 - 272 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/117 | |
dc.identifier.eissn | 1532-1827 | |
dc.identifier.doi | 10.1038/bjc.2016.188 | |
dc.description.abstract | BACKGROUND: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian randomisation (MR) analysis to examine the relationship between adiposity and CRC. METHODS: We used SNPs associated with adult body mass index (BMI), waist-hip ratio (WHR), childhood obesity and birth weight as instrumental variables in a MR analysis of 9254 CRC cases and 18 386 controls. RESULTS: In the MR analysis, the odds ratios (ORs) of CRC risk per unit increase in BMI, WHR and childhood obesity were 1.23 (95% CI: 1.02-1.49, P=0.033), 1.59 (95% CI: 1.08-2.34, P=0.019) and 1.07 (95% CI: 1.03-1.13, P=0.018), respectively. There was no evidence for association between birth weight and CRC (OR=1.22, 95% CI: 0.89-1.67, P=0.22). Combining these data with a concurrent MR-based analysis for BMI and WHR with CRC risk (totalling to 18 190 cases, 27 617 controls) provided increased support, ORs for BMI and WHR were 1.26 (95% CI: 1.10-1.44, P=7.7 × 10(-4)) and 1.40 (95% CI: 1.14-1.72, P=1.2 × 10(-3)), respectively. CONCLUSIONS: These data provide further evidence for a strong causal relationship between adiposity and the risk of developing CRC highlighting the urgent need for prevention and treatment of adiposity. | |
dc.format | Print-Electronic | |
dc.format.extent | 266 - 272 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Colorectal Neoplasms | |
dc.subject | Random Allocation | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Adult | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Adiposity | |
dc.subject | Genome-Wide Association Study | |
dc.title | Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-05-14 | |
rioxxterms.versionofrecord | 10.1038/bjc.2016.188 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | British journal of cancer | |
pubs.issue | 2 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.publication-status | Published | |
pubs.volume | 115 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Cancer Genomics | |
dc.contributor.icrauthor | Law, Philip | |
dc.contributor.icrauthor | Houlston, Richard | |