dc.contributor.author | Zhao, Z | |
dc.contributor.author | Wen, W | |
dc.contributor.author | Michailidou, K | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Zhang, B | |
dc.contributor.author | Long, J | |
dc.contributor.author | Shu, X-O | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Lindstrom, S | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Ahsan, H | |
dc.contributor.author | Aittomäki, K | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Arndt, V | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Beeghly-Fadiel, A | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Bogdanova, NV | |
dc.contributor.author | Børresen-Dale, A-L | |
dc.contributor.author | Brand, J | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Cai, Q | |
dc.contributor.author | Casey, G | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Cox, A | |
dc.contributor.author | Cross, SS | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Dumont, M | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Figueroa, J | |
dc.contributor.author | Flesch-Janys, D | |
dc.contributor.author | Fletcher, O | |
dc.contributor.author | Flyger, H | |
dc.contributor.author | Fostira, F | |
dc.contributor.author | Gammon, M | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Guénel, P | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Harrington, P | |
dc.contributor.author | Hartman, M | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | Jasmine, F | |
dc.contributor.author | John, EM | |
dc.contributor.author | Johnson, N | |
dc.contributor.author | Kabisch, M | |
dc.contributor.author | Khan, S | |
dc.contributor.author | Kibriya, M | |
dc.contributor.author | Knight, JA | |
dc.contributor.author | Kosma, V-M | |
dc.contributor.author | Kriege, M | |
dc.contributor.author | Kristensen, V | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Lee, E | |
dc.contributor.author | Li, J | |
dc.contributor.author | Lindblom, A | |
dc.contributor.author | Lophatananon, A | |
dc.contributor.author | Luben, R | |
dc.contributor.author | Lubinski, J | |
dc.contributor.author | Malone, KE | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Manoukian, S | |
dc.contributor.author | Margolin, S | |
dc.contributor.author | Marme, F | |
dc.contributor.author | McLean, C | |
dc.contributor.author | Meijers-Heijboer, H | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Miao, H | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Neven, P | |
dc.contributor.author | Olson, JE | |
dc.contributor.author | Perkins, B | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Phillips, K-A | |
dc.contributor.author | Pylkäs, K | |
dc.contributor.author | Rudolph, A | |
dc.contributor.author | Santella, R | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Schoemaker, M | |
dc.contributor.author | Shah, M | |
dc.contributor.author | Shrubsole, M | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Toland, AE | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Torres, D | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Ursin, G | |
dc.contributor.author | Van Der Luijt, RB | |
dc.contributor.author | Verhoef, S | |
dc.contributor.author | Wang-Gohrke, S | |
dc.contributor.author | Whittemore, AS | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Pilar Zamora, M | |
dc.contributor.author | Zhao, H | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Pharoah, P | |
dc.contributor.author | Hunter, D | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Zheng, W | |
dc.date.accessioned | 2016-09-28T14:20:43Z | |
dc.date.issued | 2016-05-01 | |
dc.identifier.citation | Cancer causes & control : CCC, 2016, 27 (5), pp. 679 - 693 | |
dc.identifier.issn | 0957-5243 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/147 | |
dc.identifier.eissn | 1573-7225 | |
dc.identifier.doi | 10.1007/s10552-016-0741-6 | |
dc.description.abstract | PURPOSE: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors. METHODS: We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies. RESULTS: The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04). CONCLUSIONS: We have shown that several genetic risk variants were associated with the risk of both T2D and breast cancer. However, overall genetic susceptibility to T2D may not be related to breast cancer risk. | |
dc.format | Print-Electronic | |
dc.format.extent | 679 - 693 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | SPRINGER | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Diabetes Mellitus, Type 2 | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Odds Ratio | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Middle Aged | |
dc.subject | European Continental Ancestry Group | |
dc.subject | Ethnic Groups | |
dc.subject | Female | |
dc.subject | Genetic Variation | |
dc.title | Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-03-25 | |
rioxxterms.versionofrecord | 10.1007/s10552-016-0741-6 | |
rioxxterms.licenseref.startdate | 2016-05 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Cancer causes & control : CCC | |
pubs.issue | 5 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.publication-status | Published | |
pubs.volume | 27 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Functional Genetic Epidemiology | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Fletcher, Olivia | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
dc.contributor.icrauthor | Swerdlow, Anthony | |