dc.contributor.author | Mackay, A | |
dc.contributor.author | Burford, A | |
dc.contributor.author | Carvalho, D | |
dc.contributor.author | Izquierdo, E | |
dc.contributor.author | Fazal-Salom, J | |
dc.contributor.author | Taylor, KR | |
dc.contributor.author | Bjerke, L | |
dc.contributor.author | Clarke, M | |
dc.contributor.author | Vinci, M | |
dc.contributor.author | Nandhabalan, M | |
dc.contributor.author | Temelso, S | |
dc.contributor.author | Popov, S | |
dc.contributor.author | Molinari, V | |
dc.contributor.author | Raman, P | |
dc.contributor.author | Waanders, AJ | |
dc.contributor.author | Han, HJ | |
dc.contributor.author | Gupta, S | |
dc.contributor.author | Marshall, L | |
dc.contributor.author | Zacharoulis, S | |
dc.contributor.author | Vaidya, S | |
dc.contributor.author | Mandeville, HC | |
dc.contributor.author | Bridges, LR | |
dc.contributor.author | Martin, AJ | |
dc.contributor.author | Al-Sarraj, S | |
dc.contributor.author | Chandler, C | |
dc.contributor.author | Ng, H-K | |
dc.contributor.author | Li, X | |
dc.contributor.author | Mu, K | |
dc.contributor.author | Trabelsi, S | |
dc.contributor.author | Brahim, DH-B | |
dc.contributor.author | Kisljakov, AN | |
dc.contributor.author | Konovalov, DM | |
dc.contributor.author | Moore, AS | |
dc.contributor.author | Carcaboso, AM | |
dc.contributor.author | Sunol, M | |
dc.contributor.author | de Torres, C | |
dc.contributor.author | Cruz, O | |
dc.contributor.author | Mora, J | |
dc.contributor.author | Shats, LI | |
dc.contributor.author | Stavale, JN | |
dc.contributor.author | Bidinotto, LT | |
dc.contributor.author | Reis, RM | |
dc.contributor.author | Entz-Werle, N | |
dc.contributor.author | Farrell, M | |
dc.contributor.author | Cryan, J | |
dc.contributor.author | Crimmins, D | |
dc.contributor.author | Caird, J | |
dc.contributor.author | Pears, J | |
dc.contributor.author | Monje, M | |
dc.contributor.author | Debily, M-A | |
dc.contributor.author | Castel, D | |
dc.contributor.author | Grill, J | |
dc.contributor.author | Hawkins, C | |
dc.contributor.author | Nikbakht, H | |
dc.contributor.author | Jabado, N | |
dc.contributor.author | Baker, SJ | |
dc.contributor.author | Pfister, SM | |
dc.contributor.author | Jones, DTW | |
dc.contributor.author | Fouladi, M | |
dc.contributor.author | von Bueren, AO | |
dc.contributor.author | Baudis, M | |
dc.contributor.author | Resnick, A | |
dc.contributor.author | Jones, C | |
dc.date.accessioned | 2017-08-30T14:35:56Z | |
dc.date.accessioned | 2018-01-05T09:48:46Z | |
dc.date.accessioned | 2018-03-27T10:14:35Z | |
dc.date.issued | 2017-10-09 | |
dc.identifier.citation | Cancer cell, 2017, 32 (4), pp. 520 - 537.e5 | |
dc.identifier.issn | 1535-6108 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1609 | |
dc.identifier.eissn | 1878-3686 | |
dc.identifier.doi | 10.1016/j.ccell.2017.08.017 | |
dc.description.abstract | We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification. | |
dc.format | Print-Electronic | |
dc.format.extent | 520 - 537.e5 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | CELL PRESS | |
dc.relation.replaces | https://repository.icr.ac.uk/handle/internal/802 | |
dc.relation.replaces | internal/802 | |
dc.relation.replaces | https://repository.icr.ac.uk/handle/internal/991 | |
dc.relation.replaces | internal/991 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Glioma | |
dc.subject | Brain Stem Neoplasms | |
dc.subject | DNA Topoisomerases, Type I | |
dc.subject | Ubiquitin-Protein Ligases | |
dc.subject | F-Box Proteins | |
dc.subject | Cell Cycle Proteins | |
dc.subject | Proto-Oncogene Proteins | |
dc.subject | Histones | |
dc.subject | Repressor Proteins | |
dc.subject | Gene Dosage | |
dc.subject | Mutation | |
dc.subject | Adolescent | |
dc.subject | Child | |
dc.subject | Child, Preschool | |
dc.subject | Infant | |
dc.subject | Infant, Newborn | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Young Adult | |
dc.subject | Exome | |
dc.subject | F-Box-WD Repeat-Containing Protein 7 | |
dc.title | Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-08-29 | |
rioxxterms.funder | The Institute of Cancer Research | |
rioxxterms.identifier.project | Unspecified | |
rioxxterms.versionofrecord | 10.1016/j.ccell.2017.08.017 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2017-10 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Cancer cell | |
pubs.issue | 4 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Glioma Team | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Glioma Team | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Paediatric and Adolescent Radiotherapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Glioma Team | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Glioma Team | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Paediatric and Adolescent Radiotherapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 32 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Glioma Team | |
icr.researchteam | Paediatric and Adolescent Radiotherapy | |
dc.contributor.icrauthor | Mackay, Alan | |
dc.contributor.icrauthor | Bjerke, Lynn | |
dc.contributor.icrauthor | Clarke, Matthew | |
dc.contributor.icrauthor | Molinari, Valeria | |
dc.contributor.icrauthor | Jones, Chris | |