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dc.contributor.authorBrocklesby, KLen_US
dc.contributor.authorWaby, JSen_US
dc.contributor.authorCawthorne, Cen_US
dc.contributor.authorSmith, Gen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-03-28T11:45:51Z
dc.date.issued2018-04-25en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29706675en_US
dc.identifierS0040-4039(18)30353-8en_US
dc.identifier.citationTetrahedron Lett, 2018, 59 (17), pp. 1635 - 1637en_US
dc.identifier.issn0040-4039en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1618
dc.identifier.doi10.1016/j.tetlet.2018.03.039en_US
dc.description.abstractFluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted motifs. One such area is the fluoromethyl group, particularly when required in a fluoroalkylating capacity. The cold fluorination of methylene ditosylate is under evaluated in the literature, often proceeding with low yields or harsh conditions. This report describes a novel microwave method for the rapid nucleophilic fluorination of methylene ditosylate using inexpensive reagents in good isolated yield (65%).en_US
dc.format.extent1635 - 1637en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectFluorinationen_US
dc.subjectFluoromethyl tosylateen_US
dc.subjectMicrowaveen_US
dc.subjectPETen_US
dc.subjectTert-amyl alcoholen_US
dc.titleA practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-03-15en_US
rioxxterms.versionofrecord10.1016/j.tetlet.2018.03.039en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2018-04-25en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfTetrahedron Letten_US
pubs.issue17en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/PET Radiochemistry
pubs.publication-statusPublisheden_US
pubs.volume59en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamPET Radiochemistryen_US
dc.contributor.icrauthorSmith, Grahamen_US


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