dc.contributor.author | Brocklesby, KL | |
dc.contributor.author | Waby, JS | |
dc.contributor.author | Cawthorne, C | |
dc.contributor.author | Smith, G | |
dc.date.accessioned | 2018-03-28T11:45:51Z | |
dc.date.issued | 2018-04-25 | |
dc.identifier.citation | Tetrahedron letters, 2018, 59 (17), pp. 1635 - 1637 | |
dc.identifier.issn | 0040-4039 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1618 | |
dc.identifier.doi | 10.1016/j.tetlet.2018.03.039 | |
dc.description.abstract | Fluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted motifs. One such area is the fluoromethyl group, particularly when required in a fluoroalkylating capacity. The cold fluorination of methylene ditosylate is under evaluated in the literature, often proceeding with low yields or harsh conditions. This report describes a novel microwave method for the rapid nucleophilic fluorination of methylene ditosylate using inexpensive reagents in good isolated yield (65%). | |
dc.format | Print | |
dc.format.extent | 1635 - 1637 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-03-15 | |
rioxxterms.versionofrecord | 10.1016/j.tetlet.2018.03.039 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2018-04 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Tetrahedron letters | |
pubs.issue | 17 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/PET Radiochemistry | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/PET Radiochemistry | |
pubs.publication-status | Published | |
pubs.volume | 59 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | PET Radiochemistry | |
dc.contributor.icrauthor | Smith, Graham | |