dc.contributor.author | Abubakar, M | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Ali, HR | |
dc.contributor.author | Chatterjee, N | |
dc.contributor.author | Coulson, P | |
dc.contributor.author | Daley, F | |
dc.contributor.author | Blows, F | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Stegmaier, C | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Rudolph, A | |
dc.contributor.author | Sinn, P | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Devilee, P | |
dc.contributor.author | Tollenaar, RAEM | |
dc.contributor.author | Seynaeve, C | |
dc.contributor.author | Figueroa, J | |
dc.contributor.author | Lissowska, J | |
dc.contributor.author | Hewitt, S | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | Hollestelle, A | |
dc.contributor.author | Foekens, R | |
dc.contributor.author | Koppert, LB | |
dc.contributor.author | kConFab Investigators, | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Jones, ME | |
dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Keeman, R | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Sherman, ME | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Pharoah, PD | |
dc.contributor.author | Garcia-Closas, M | |
dc.date.accessioned | 2018-04-17T09:12:42Z | |
dc.date.issued | 2018-08-15 | |
dc.identifier.citation | International journal of cancer, 2018, 143 (4), pp. 746 - 757 | |
dc.identifier.issn | 0020-7136 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1647 | |
dc.identifier.eissn | 1097-0215 | |
dc.identifier.doi | 10.1002/ijc.31352 | |
dc.description.abstract | Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ breast cancer cases and 26,281 controls from 11 epidemiological studies. Proliferation was determined by centralized automated measures of KI67 in tissue microarrays. Odds ratios (OR), 95% confidence intervals (CI) and p-values for case-case and case-control comparisons for risk factors in relation to levels of grade and quartiles (Q1-Q4) of KI67 were estimated using polytomous logistic regression models. Case-case comparisons showed associations between nulliparity and high KI67 [OR (95% CI) for Q4 vs. Q1 = 1.54 (1.22, 1.95)]; obesity and high grade [grade 3 vs. 1 = 1.68 (1.31, 2.16)] and current use of combined hormone therapy (HT) and low grade [grade 3 vs. 1 = 0.27 (0.16, 0.44)] tumors. In case-control comparisons, nulliparity was associated with elevated risk of tumors with high but not low levels of proliferation [1.43 (1.14, 1.81) for KI67 Q4 vs. 0.83 (0.60, 1.14) for KI67 Q1]; obesity among women ≥50 years with high but not low grade tumors [1.55 (1.17, 2.06) for grade 3 vs. 0.88 (0.66, 1.16) for grade 1] and HT with low but not high grade tumors [3.07 (2.22, 4.23) for grade 1 vs. 0.85 (0.55, 1.30) for grade 3]. Menarcheal age and family history were similarly associated with HR+ tumors of different grade or KI67 levels. These findings provide insights into the etiologic heterogeneity of HR+ tumors. | |
dc.format | Print-Electronic | |
dc.format.extent | 746 - 757 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | kConFab Investigators | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Obesity | |
dc.subject | Contraceptives, Oral, Hormonal | |
dc.subject | Ki-67 Antigen | |
dc.subject | Receptors, Estrogen | |
dc.subject | Receptors, Progesterone | |
dc.subject | Body Mass Index | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Parity | |
dc.subject | Cell Proliferation | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Neoplasm Grading | |
dc.subject | Biomarkers, Tumor | |
dc.title | Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-01-26 | |
rioxxterms.versionofrecord | 10.1002/ijc.31352 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2018-08 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | International journal of cancer | |
pubs.issue | 4 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.publication-status | Published | |
pubs.volume | 143 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Abubakar, Mustapha | |
dc.contributor.icrauthor | Jones, Michael | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Garcia-Closas, Montserrat | |