dc.contributor.author | Horne, HN | |
dc.contributor.author | Oh, H | |
dc.contributor.author | Sherman, ME | |
dc.contributor.author | Palakal, M | |
dc.contributor.author | Hewitt, SM | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | Hardisson, D | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Cora, R | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Cuk, K | |
dc.contributor.author | Devilee, P | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Eccles, DM | |
dc.contributor.author | Eilber, U | |
dc.contributor.author | Hartikainen, JM | |
dc.contributor.author | Heikkilä, P | |
dc.contributor.author | Holleczek, B | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | Jones, M | |
dc.contributor.author | Keeman, R | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Martens, JWM | |
dc.contributor.author | Muranen, TA | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Olson, JE | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Perez, JIA | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Ruddy, KJ | |
dc.contributor.author | Saum, K-U | |
dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Seynaeve, C | |
dc.contributor.author | Sironen, R | |
dc.contributor.author | Smit, VTHBM | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Tengström, M | |
dc.contributor.author | Thomas, AS | |
dc.contributor.author | Timmermans, AM | |
dc.contributor.author | Tollenaar, RAEM | |
dc.contributor.author | Troester, MA | |
dc.contributor.author | van Asperen, CJ | |
dc.contributor.author | van Deurzen, CHM | |
dc.contributor.author | Van Leeuwen, FF | |
dc.contributor.author | Van't Veer, LJ | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | Figueroa, JD | |
dc.date.accessioned | 2018-05-17T14:30:19Z | |
dc.date.issued | 2018-04-26 | |
dc.identifier.citation | Scientific reports, 2018, 8 (1), pp. 6574 - ? | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1674 | |
dc.identifier.eissn | 2045-2322 | |
dc.identifier.doi | 10.1038/s41598-018-23733-4 | |
dc.description.abstract | E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes. | |
dc.format | Electronic | |
dc.format.extent | 6574 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Receptor, erbB-2 | |
dc.subject | Cadherins | |
dc.subject | Receptors, Estrogen | |
dc.subject | Receptors, Progesterone | |
dc.subject | Prognosis | |
dc.subject | Proportional Hazards Models | |
dc.subject | Odds Ratio | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Gene Expression | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Biomarkers, Tumor | |
dc.title | E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-03-16 | |
rioxxterms.versionofrecord | 10.1038/s41598-018-23733-4 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2018-04-26 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Scientific reports | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.publication-status | Published | |
pubs.volume | 8 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Complex Trait Genetics | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Jones, Michael | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
dc.contributor.icrauthor | Swerdlow, Anthony | |