Show simple item record

dc.contributor.authorHorne, HN
dc.contributor.authorOh, H
dc.contributor.authorSherman, ME
dc.contributor.authorPalakal, M
dc.contributor.authorHewitt, SM
dc.contributor.authorSchmidt, MK
dc.contributor.authorMilne, RL
dc.contributor.authorHardisson, D
dc.contributor.authorBenitez, J
dc.contributor.authorBlomqvist, C
dc.contributor.authorBolla, MK
dc.contributor.authorBrenner, H
dc.contributor.authorChang-Claude, J
dc.contributor.authorCora, R
dc.contributor.authorCouch, FJ
dc.contributor.authorCuk, K
dc.contributor.authorDevilee, P
dc.contributor.authorEaston, DF
dc.contributor.authorEccles, DM
dc.contributor.authorEilber, U
dc.contributor.authorHartikainen, JM
dc.contributor.authorHeikkilä, P
dc.contributor.authorHolleczek, B
dc.contributor.authorHooning, MJ
dc.contributor.authorJones, M
dc.contributor.authorKeeman, R
dc.contributor.authorMannermaa, A
dc.contributor.authorMartens, JWM
dc.contributor.authorMuranen, TA
dc.contributor.authorNevanlinna, H
dc.contributor.authorOlson, JE
dc.contributor.authorOrr, N
dc.contributor.authorPerez, JIA
dc.contributor.authorPharoah, PDP
dc.contributor.authorRuddy, KJ
dc.contributor.authorSaum, K-U
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorSeynaeve, C
dc.contributor.authorSironen, R
dc.contributor.authorSmit, VTHBM
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTengström, M
dc.contributor.authorThomas, AS
dc.contributor.authorTimmermans, AM
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorTroester, MA
dc.contributor.authorvan Asperen, CJ
dc.contributor.authorvan Deurzen, CHM
dc.contributor.authorVan Leeuwen, FF
dc.contributor.authorVan't Veer, LJ
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorFigueroa, JD
dc.date.accessioned2018-05-17T14:30:19Z
dc.date.issued2018-04-26
dc.identifier.citationScientific reports, 2018, 8 (1), pp. 6574 - ?
dc.identifier.issn2045-2322
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1674
dc.identifier.eissn2045-2322
dc.identifier.doi10.1038/s41598-018-23733-4
dc.description.abstractE-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes.
dc.formatElectronic
dc.format.extent6574 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectReceptor, erbB-2
dc.subjectCadherins
dc.subjectReceptors, Estrogen
dc.subjectReceptors, Progesterone
dc.subjectPrognosis
dc.subjectProportional Hazards Models
dc.subjectOdds Ratio
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectGene Expression
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectBiomarkers, Tumor
dc.titleE-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.
dc.typeJournal Article
dcterms.dateAccepted2018-03-16
rioxxterms.versionofrecord10.1038/s41598-018-23733-4
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-04-26
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfScientific reports
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume8
pubs.embargo.termsNot known
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorOrr, Nicholasen
dc.contributor.icrauthorSchoemaker, Minouken
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorJones, Michaelen


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0