dc.contributor.author | Wyszynski, A | |
dc.contributor.author | Hong, C-C | |
dc.contributor.author | Lam, K | |
dc.contributor.author | Michailidou, K | |
dc.contributor.author | Lytle, C | |
dc.contributor.author | Yao, S | |
dc.contributor.author | Zhang, Y | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Broeks, A | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Lophatananon, A | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Dos-Santos-Silva, I | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Marme, F | |
dc.contributor.author | Guénel, P | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | González-Neira, A | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Dieffenbach, AK | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | GENICA Network, | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Khan, S | |
dc.contributor.author | Matsuo, K | |
dc.contributor.author | Ito, H | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Bogdanova, NV | |
dc.contributor.author | Lindblom, A | |
dc.contributor.author | Margolin, S | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Kosma, V-M | |
dc.contributor.author | kConFab Investigators, | |
dc.contributor.author | Australian Ovarian Cancer Study Group, | |
dc.contributor.author | Wu, AH | |
dc.contributor.author | Van Den Berg, D | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Wildiers, H | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Rudolph, A | |
dc.contributor.author | Radice, P | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Olson, JE | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Henderson, BE | |
dc.contributor.author | Dumont, M | |
dc.contributor.author | Teo, SH | |
dc.contributor.author | Wong, TY | |
dc.contributor.author | Kristensen, V | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Long, J | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Pylkäs, K | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Knight, JA | |
dc.contributor.author | Devilee, P | |
dc.contributor.author | Seynaeve, C | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | Figueroa, J | |
dc.contributor.author | Klevebring, D | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | van den Ouweland, AMW | |
dc.contributor.author | Darabi, H | |
dc.contributor.author | Shu, X-O | |
dc.contributor.author | Gao, Y-T | |
dc.contributor.author | Cox, A | |
dc.contributor.author | Blot, W | |
dc.contributor.author | Signorello, LB | |
dc.contributor.author | Shah, M | |
dc.contributor.author | Kang, D | |
dc.contributor.author | Choi, J-Y | |
dc.contributor.author | Hartman, M | |
dc.contributor.author | Miao, H | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | Lubinski, J | |
dc.contributor.author | Sangrajrang, S | |
dc.contributor.author | McKay, J | |
dc.contributor.author | Toland, AE | |
dc.contributor.author | Yannoukakos, D | |
dc.contributor.author | Shen, C-Y | |
dc.contributor.author | Wu, P-E | |
dc.contributor.author | Swerdlow, A | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Bandera, E | |
dc.contributor.author | Amos, C | |
dc.contributor.author | Ambrosone, C | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Cole, MD | |
dc.date.accessioned | 2016-10-14T15:42:43Z | |
dc.date.issued | 2016-09-01 | |
dc.identifier.citation | Human molecular genetics, 2016, 25 (17), pp. 3863 - 3876 | |
dc.identifier.issn | 0964-6906 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/168 | |
dc.identifier.eissn | 1460-2083 | |
dc.identifier.doi | 10.1093/hmg/ddw223 | |
dc.description.abstract | Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females. Previous association studies have identified variants on 2q35 associated with the risk of breast cancer. To identify functional susceptibility loci for breast cancer, we interrogated the 2q35 gene desert for chromatin architecture and functional variation correlated with gene expression. We report a novel intergenic breast cancer risk locus containing an enhancer copy number variation (enCNV; deletion) located approximately 400Kb upstream to IGFBP5, which overlaps an intergenic ERα-bound enhancer that loops to the IGFBP5 promoter. The enCNV is correlated with modified ERα binding and monoallelic-repression of IGFBP5 following oestrogen treatment. We investigated the association of enCNV genotype with breast cancer in 1,182 cases and 1,362 controls, and replicate our findings in an independent set of 62,533 cases and 60,966 controls from 41 case control studies and 11 GWAS. We report a dose-dependent inverse association of 2q35 enCNV genotype (percopy OR = 0.68 95%CI 0.55-0.83, P = 0.0002; replication OR = 0.77 95% CI 0.73-0.82, P = 2.1 × 10-19) and identify 13 additional linked variants (r2 > 0.8) in the 20Kb linkage block containing the enCNV (P = 3.2 × 10-15 - 5.6 × 10-17). These associations were independent of previously reported 2q35 variants, rs13387042/rs4442975 and rs16857609, and were stronger for ER-positive than ER-negative disease. Together, these results suggest that 2q35 breast cancer risk loci may be mediating their effect through IGFBP5. | |
dc.format | Print-Electronic | |
dc.format.extent | 3863 - 3876 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | OXFORD UNIV PRESS | |
dc.subject | GENICA Network | |
dc.subject | kConFab Investigators | |
dc.subject | Australian Ovarian Cancer Study Group | |
dc.subject | Chromosomes, Human, Pair 2 | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Carrier Proteins | |
dc.subject | Insulin-Like Growth Factor Binding Protein 5 | |
dc.subject | Case-Control Studies | |
dc.subject | Gene Expression Regulation, Neoplastic | |
dc.subject | Sequence Deletion | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Enhancer Elements, Genetic | |
dc.subject | Promoter Regions, Genetic | |
dc.subject | Young Adult | |
dc.subject | MCF-7 Cells | |
dc.title | An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-07-04 | |
rioxxterms.versionofrecord | 10.1093/hmg/ddw223 | |
rioxxterms.licenseref.startdate | 2016-09 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Human molecular genetics | |
pubs.issue | 17 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.publication-status | Published | |
pubs.volume | 25 | |
pubs.embargo.terms | No embargo | |
pubs.oa-location | http://hmg.oxfordjournals.org/content/early/2016/08/19/hmg.ddw223.full.pdf+html | |
icr.researchteam | Complex Trait Genetics | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Swerdlow, Anthony | |