dc.contributor.author | Gao, Q | |
dc.contributor.author | López-Knowles, E | |
dc.contributor.author | U Cheang, MC | |
dc.contributor.author | Morden, J | |
dc.contributor.author | Ribas, R | |
dc.contributor.author | Sidhu, K | |
dc.contributor.author | Evans, D | |
dc.contributor.author | Martins, V | |
dc.contributor.author | Dodson, A | |
dc.contributor.author | Skene, A | |
dc.contributor.author | Holcombe, C | |
dc.contributor.author | Mallon, E | |
dc.contributor.author | Evans, A | |
dc.contributor.author | Bliss, JM | |
dc.contributor.author | Robertson, J | |
dc.contributor.author | Smith, I | |
dc.contributor.author | Martin, L-A | |
dc.contributor.author | Dowsett, M | |
dc.contributor.author | POETIC Trial Management Group and Trialists, | |
dc.date.accessioned | 2018-05-29T13:25:51Z | |
dc.date.issued | 2018-05-22 | |
dc.identifier.citation | JNCI cancer spectrum, 2018, 2 (2), pp. pky005 - ? | |
dc.identifier.issn | 2515-5091 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1693 | |
dc.identifier.eissn | 2515-5091 | |
dc.identifier.doi | 10.1093/jncics/pky005 | |
dc.description.abstract | To investigate the impact of sampling methodology on gene expression data from primary estrogen receptor-positive (ER+) breast cancer biopsies, global gene expression was measured in core-cut biopsies at baseline and surgery from patients randomly assigned to receive either two weeks of presurgical aromatase inhibitor (AI; n = 157) or no presurgical treatment (n = 56). Those genes most markedly altered in the AI group (eg, FOS, DUSP1, RGS1, FOSB) were similarly altered in the no treatment group; some widely investigated genes that were apparently unaffected in the AI group (eg, MYC) were counter-altered in the control group, masking actual AI-dependent changes. In the absence of a control group, these artefactual changes would likely lead to the most affected genes being the erroneous focus of research. The findings are likely relevant to all archival collections of ER+ breast cancer. | |
dc.format | Electronic-eCollection | |
dc.format.extent | pky005 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | OXFORD UNIV PRESS | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | POETIC Trial Management Group and Trialists | |
dc.title | Major Impact of Sampling Methodology on Gene Expression in Estrogen Receptor-Positive Breast Cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-02-16 | |
rioxxterms.versionofrecord | 10.1093/jncics/pky005 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
rioxxterms.licenseref.startdate | 2018-04 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | JNCI cancer spectrum | |
pubs.issue | 2 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Genomic Analysis – Clinical Trials | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.) | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Genomic Analysis – Clinical Trials | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.) | |
pubs.publication-status | Published | |
pubs.volume | 2 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Clinical Trials & Statistics Unit | |
icr.researchteam | Genomic Analysis – Clinical Trials | |
icr.researchteam | Endocrinology | |
dc.contributor.icrauthor | Gao, Qiong | |
dc.contributor.icrauthor | Bliss, Judith | |