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dc.contributor.authorFarrugia, AJ
dc.contributor.authorCalvo, F
dc.date.accessioned2016-10-19T16:15:47Z
dc.date.issued2017-01-02
dc.identifier.citationSmall GTPases, 2017, 8 (1), pp. 49 - 57
dc.identifier.issn2154-1248
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/176
dc.identifier.eissn2154-1256
dc.identifier.doi10.1080/21541248.2016.1194952
dc.description.abstractRho family GTPases such as Cdc42 are key regulators of essential cellular processes through their effects on cytoskeletal dynamics, signaling and gene expression. Rho GTPases modulate these functions by engaging a wide variety of downstream effectors. Among these effectors is the largely understudied Cdc42EP/BORG family of Cdc42 effectors. BORG proteins have been linked to actin and septin regulation, but their role in development and disease is only starting to emerge. Recently, Cdc42EP3/BORG2 was shown to coordinate actin and septin cytoskeleton rearrangements in cancer-associated fibroblasts (CAFs). Interestingly, Cdc42EP3 expression potentiated cellular responses to mechanical stimulation leading to signaling and transcriptional adaptations required for the emergence of a fully activated CAF phenotype. These findings uncover a novel role for the BORG/septin network in cancer. Here, we demonstrate that Cdc42EP3 function in CAFs relies on tight regulation by Cdc42.
dc.formatPrint-Electronic
dc.format.extent49 - 57
dc.languageeng
dc.language.isoeng
dc.publisherInforma UK Limited
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectActins
dc.subjectcdc42 GTP-Binding Protein
dc.subjectGTP-Binding Protein Regulators
dc.subjectSignal Transduction
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectSeptins
dc.subjectCancer-Associated Fibroblasts
dc.titleCdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.
dc.typeJournal Article
dcterms.dateAccepted2016-05-23
rioxxterms.versionofrecord10.1080/21541248.2016.1194952
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfSmall GTPases
pubs.issue1
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Tumour Microenvironment
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Tumour Microenvironment
pubs.publication-statusPublished
pubs.volume8
pubs.embargo.termsNo embargo
icr.researchteamTumour Microenvironment
dc.contributor.icrauthorFarrugia, Aaron


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