Show simple item record

dc.contributor.authorCooke, R
dc.contributor.authorJones, ME
dc.contributor.authorCunningham, D
dc.contributor.authorFalk, SJ
dc.contributor.authorGilson, D
dc.contributor.authorHancock, BW
dc.contributor.authorHarris, SJ
dc.contributor.authorHorwich, A
dc.contributor.authorHoskin, PJ
dc.contributor.authorIllidge, T
dc.contributor.authorLinch, DC
dc.contributor.authorLister, TA
dc.contributor.authorLucraft, HH
dc.contributor.authorRadford, JA
dc.contributor.authorStevens, AM
dc.contributor.authorSyndikus, I
dc.contributor.authorWilliams, MV
dc.contributor.authorEngland and Wales Hodgkin Lymphoma Follow-up Group
dc.contributor.authorSwerdlow, AJ
dc.date.accessioned2018-06-13T10:21:40Z
dc.date.issued2013-06
dc.identifier.citationBritish journal of cancer, 2013, 108 (11), pp. 2399 - 2406
dc.identifier.issn0007-0920
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1855
dc.identifier.eissn1532-1827en_US
dc.identifier.doi10.1038/bjc.2013.219en_US
dc.description.abstractBackground Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors modify this risk.Methods We examined the effects of menarcheal age, pregnancy, and menopausal age on breast cancer risk following sRT in case-control data from questionnaires completed by 2497 women from a cohort of 5002 treated with sRT for HL at ages <36 during 1956-2003.Results Two-hundred and sixty women had been diagnosed with breast cancer. Breast cancer risk was significantly increased in patients treated within 6 months of menarche (odds ratio (OR) 5.52, 95% confidence interval (CI) (1.97-15.46)), and increased significantly with proximity of sRT to menarche (Ptrend<0.001). It was greatest when sRT was close to a late menarche, but based on small numbers and needing reexamination elsewhere. Risk was not significantly affected by full-term pregnancies before or after treatment. Risk was significantly reduced by early menopause (OR 0.55, 95% CI (0.35-0.85)), and increased with number of premenopausal years after treatment (Ptrend=0.003).Conclusion In summary, this paper shows for the first time that sRT close to menarche substantially increases breast cancer risk. Careful consideration should be given to follow-up of these women, and to measures that might reduce their future breast cancer risk.
dc.formatPrint-Electronic
dc.format.extent2399 - 2406
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEngland and Wales Hodgkin Lymphoma Follow-up Group
dc.subjectHumans
dc.subjectHodgkin Disease
dc.subjectBreast Neoplasms
dc.subjectNeoplasms, Radiation-Induced
dc.subjectReproductive History
dc.subjectCase-Control Studies
dc.subjectCohort Studies
dc.subjectAge Factors
dc.subjectPregnancy
dc.subjectMenarche
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectEngland
dc.subjectWales
dc.subjectFemale
dc.titleBreast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors.
dc.typeJournal Article
rioxxterms.versionofrecord10.1038/bjc.2013.219
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
rioxxterms.licenseref.startdate2013-06en_US
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBritish journal of cancer
pubs.issue11
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume108en_US
pubs.embargo.termsNot known
icr.researchteamMedicine (RMH Smith Cunningham)en_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorHorwich, Alanen
dc.contributor.icrauthorCooke, Rosieen
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorCunningham, Daviden
dc.contributor.icrauthorJones, Michaelen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/