dc.contributor.author | Cooke, R | |
dc.contributor.author | Jones, ME | |
dc.contributor.author | Cunningham, D | |
dc.contributor.author | Falk, SJ | |
dc.contributor.author | Gilson, D | |
dc.contributor.author | Hancock, BW | |
dc.contributor.author | Harris, SJ | |
dc.contributor.author | Horwich, A | |
dc.contributor.author | Hoskin, PJ | |
dc.contributor.author | Illidge, T | |
dc.contributor.author | Linch, DC | |
dc.contributor.author | Lister, TA | |
dc.contributor.author | Lucraft, HH | |
dc.contributor.author | Radford, JA | |
dc.contributor.author | Stevens, AM | |
dc.contributor.author | Syndikus, I | |
dc.contributor.author | Williams, MV | |
dc.contributor.author | England and Wales Hodgkin Lymphoma Follow-up Group, | |
dc.contributor.author | Swerdlow, AJ | |
dc.date.accessioned | 2018-06-13T10:21:40Z | |
dc.date.issued | 2013-06-11 | |
dc.identifier.citation | British journal of cancer, 2013, 108 (11), pp. 2399 - 2406 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1855 | |
dc.identifier.eissn | 1532-1827 | |
dc.identifier.doi | 10.1038/bjc.2013.219 | |
dc.description.abstract | BACKGROUND: Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors modify this risk. METHODS: We examined the effects of menarcheal age, pregnancy, and menopausal age on breast cancer risk following sRT in case-control data from questionnaires completed by 2497 women from a cohort of 5002 treated with sRT for HL at ages <36 during 1956-2003. RESULTS: Two-hundred and sixty women had been diagnosed with breast cancer. Breast cancer risk was significantly increased in patients treated within 6 months of menarche (odds ratio (OR) 5.52, 95% confidence interval (CI) (1.97-15.46)), and increased significantly with proximity of sRT to menarche (Ptrend<0.001). It was greatest when sRT was close to a late menarche, but based on small numbers and needing reexamination elsewhere. Risk was not significantly affected by full-term pregnancies before or after treatment. Risk was significantly reduced by early menopause (OR 0.55, 95% CI (0.35-0.85)), and increased with number of premenopausal years after treatment (Ptrend=0.003). CONCLUSION: In summary, this paper shows for the first time that sRT close to menarche substantially increases breast cancer risk. Careful consideration should be given to follow-up of these women, and to measures that might reduce their future breast cancer risk. | |
dc.format | Print-Electronic | |
dc.format.extent | 2399 - 2406 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | England and Wales Hodgkin Lymphoma Follow-up Group | |
dc.subject | Humans | |
dc.subject | Hodgkin Disease | |
dc.subject | Breast Neoplasms | |
dc.subject | Neoplasms, Radiation-Induced | |
dc.subject | Reproductive History | |
dc.subject | Case-Control Studies | |
dc.subject | Cohort Studies | |
dc.subject | Age Factors | |
dc.subject | Pregnancy | |
dc.subject | Menarche | |
dc.subject | Adult | |
dc.subject | Middle Aged | |
dc.subject | England | |
dc.subject | Wales | |
dc.subject | Female | |
dc.title | Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors. | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1038/bjc.2013.219 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-sa/4.0 | |
rioxxterms.licenseref.startdate | 2013-06 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | British journal of cancer | |
pubs.issue | 11 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 108 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Medicine (RMH Smith Cunningham) | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Cooke, Rosie | |
dc.contributor.icrauthor | Jones, Michael | |
dc.contributor.icrauthor | Horwich, Alan | |
dc.contributor.icrauthor | Swerdlow, Anthony | |