dc.contributor.author | Turajlic, S | |
dc.contributor.author | Xu, H | |
dc.contributor.author | Litchfield, K | |
dc.contributor.author | Rowan, A | |
dc.contributor.author | Chambers, T | |
dc.contributor.author | Lopez, JI | |
dc.contributor.author | Nicol, D | |
dc.contributor.author | O'Brien, T | |
dc.contributor.author | Larkin, J | |
dc.contributor.author | Horswell, S | |
dc.contributor.author | Stares, M | |
dc.contributor.author | Au, L | |
dc.contributor.author | Jamal-Hanjani, M | |
dc.contributor.author | Challacombe, B | |
dc.contributor.author | Chandra, A | |
dc.contributor.author | Hazell, S | |
dc.contributor.author | Eichler-Jonsson, C | |
dc.contributor.author | Soultati, A | |
dc.contributor.author | Chowdhury, S | |
dc.contributor.author | Rudman, S | |
dc.contributor.author | Lynch, J | |
dc.contributor.author | Fernando, A | |
dc.contributor.author | Stamp, G | |
dc.contributor.author | Nye, E | |
dc.contributor.author | Jabbar, F | |
dc.contributor.author | Spain, L | |
dc.contributor.author | Lall, S | |
dc.contributor.author | Guarch, R | |
dc.contributor.author | Falzon, M | |
dc.contributor.author | Proctor, I | |
dc.contributor.author | Pickering, L | |
dc.contributor.author | Gore, M | |
dc.contributor.author | Watkins, TBK | |
dc.contributor.author | Ward, S | |
dc.contributor.author | Stewart, A | |
dc.contributor.author | DiNatale, R | |
dc.contributor.author | Becerra, MF | |
dc.contributor.author | Reznik, E | |
dc.contributor.author | Hsieh, JJ | |
dc.contributor.author | Richmond, TA | |
dc.contributor.author | Mayhew, GF | |
dc.contributor.author | Hill, SM | |
dc.contributor.author | McNally, CD | |
dc.contributor.author | Jones, C | |
dc.contributor.author | Rosenbaum, H | |
dc.contributor.author | Stanislaw, S | |
dc.contributor.author | Burgess, DL | |
dc.contributor.author | Alexander, NR | |
dc.contributor.author | Swanton, C | |
dc.contributor.author | PEACE, | |
dc.contributor.author | TRACERx Renal Consortium, | |
dc.date.accessioned | 2018-06-14T09:32:34Z | |
dc.date.issued | 2018-04-19 | |
dc.identifier.citation | Cell, 2018, 173 (3), pp. 581 - 594.e12 | |
dc.identifier.issn | 0092-8674 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1870 | |
dc.identifier.eissn | 1097-4172 | |
dc.identifier.doi | 10.1016/j.cell.2018.03.057 | |
dc.description.abstract | Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis and ccRCC-related mortality (p = 0.0014). Distinct patterns of metastatic dissemination were observed, including rapid progression to multiple tissue sites seeded by primary tumors of monoclonal structure. By contrast, we observed attenuated progression in cases characterized by high primary tumor heterogeneity, with metastatic competence acquired gradually and initial progression to solitary metastasis. Finally, we observed early divergence of primitive ancestral clones and protracted latency of up to two decades as a feature of pancreatic metastases. | |
dc.format | Print-Electronic | |
dc.format.extent | 581 - 594.e12 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | CELL PRESS | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | PEACE | |
dc.subject | TRACERx Renal Consortium | |
dc.subject | Chromosomes, Human, Pair 9 | |
dc.subject | Chromosomes, Human, Pair 14 | |
dc.subject | Humans | |
dc.subject | Carcinoma, Renal Cell | |
dc.subject | Kidney Neoplasms | |
dc.subject | Neoplasm Metastasis | |
dc.subject | Thrombosis | |
dc.subject | Disease Progression | |
dc.subject | Biopsy | |
dc.subject | Treatment Outcome | |
dc.subject | Longitudinal Studies | |
dc.subject | Prospective Studies | |
dc.subject | Chromosome Mapping | |
dc.subject | Phenotype | |
dc.subject | Mutation | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Biomarkers | |
dc.title | Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-03-20 | |
rioxxterms.versionofrecord | 10.1016/j.cell.2018.03.057 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
rioxxterms.licenseref.startdate | 2018-04-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Cell | |
pubs.issue | 3 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer/Melanoma and Kidney Cancer (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Experimental Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Melanoma and Kidney Cancer/Melanoma and Kidney Cancer (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Experimental Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 173 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Melanoma and Kidney Cancer | |
icr.researchteam | Experimental Pathology | |
icr.researchteam | Molecular & Population Genetics | |
dc.contributor.icrauthor | Litchfield, Kevin | |
dc.contributor.icrauthor | Au, Lewis | |
dc.contributor.icrauthor | Spain, Lavinia | |