canSAR: an integrated cancer public translational research and drug discovery resource.
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Date
2012-01-01ICR Author
Author
Halling-Brown, MD
Bulusu, KC
Patel, M
Tym, JE
Al-Lazikani, B
Type
Journal Article
Metadata
Show full item recordAbstract
canSAR is a fully integrated cancer research and drug discovery resource developed to utilize the growing publicly available biological annotation, chemical screening, RNA interference screening, expression, amplification and 3D structural data. Scientists can, in a single place, rapidly identify biological annotation of a target, its structural characterization, expression levels and protein interaction data, as well as suitable cell lines for experiments, potential tool compounds and similarity to known drug targets. canSAR has, from the outset, been completely use-case driven which has dramatically influenced the design of the back-end and the functionality provided through the interfaces. The Web interface at http://cansar.icr.ac.uk provides flexible, multipoint entry into canSAR. This allows easy access to the multidisciplinary data within, including target and compound synopses, bioactivity views and expert tools for chemogenomic, expression and protein interaction network data.
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Subject
Cell Line, Tumor
Humans
Neoplasms
Antineoplastic Agents
Gene Expression
RNA Interference
Models, Molecular
Systems Integration
Internet
Databases, Genetic
Genetic Variation
Drug Discovery
Translational Medical Research
Protein Interaction Maps
Research team
Computational Biology and Chemogenomics
Language
eng
License start date
2012-01
Citation
Nucleic acids research, 2012, 40 (Database issue), pp. D947 - D956
Publisher
OXFORD UNIV PRESS