Browsing Breast Cancer Research by author "Brisken, Cathrin"
Now showing items 1-20 of 23
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90 YEARS OF PROGESTERONE: Progesterone receptor signaling in the normal breast and its implications for cancer.
Brisken, C; Scabia, V (BIOSCIENTIFICA LTD, 2020-07-01)Progesterone is considered as the pregnancy hormone and acts on many different target tissues. Progesterone receptor (PR) signaling is important for normal development and the physiologic function of the breast and impinges ... -
A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids.
Laszlo, CF; Paz Montoya, J; Shamseddin, M; De Martino, F; Beguin, A; et al. (ELSEVIER, 2019-10-25)In the context of hormonal contraception and hormone replacement therapy (HRT), many women are exposed to exogenous hormones. Current use of hormonal contraception with combined ethinyl estradiol and different progestins ... -
A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures.
Cartaxo, AL; Estrada, MF; Domenici, G; Roque, R; Silva, F; et al. (BMC, 2020-08-17)BACKGROUND: Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) ... -
Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development.
Ataca, D; Caikovski, M; Piersigilli, A; Moulin, A; Benarafa, C; et al. (COMPANY OF BIOLOGISTS LTD, 2016-11-15)The ADAMTS family comprises 19 secreted metalloproteinases that cleave extracellular matrix components and have diverse functions in numerous disease and physiological contexts. A number of them remain 'orphan' proteases ... -
ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels.
Bernier-Latmani, J; Mauri, C; Marcone, R; Renevey, F; Durot, S; et al. (NATURE PORTFOLIO, 2022-07-09)The small intestinal villus tip is the first point of contact for lumen-derived substances including nutrients and microbial products. Electron microscopy studies from the early 1970s uncovered unusual spatial organization ... -
Atlas of Lobular Breast Cancer Models: Challenges and Strategic Directions.
Sflomos, G; Schipper, K; Koorman, T; Fitzpatrick, A; Oesterreich, S; et al. (MDPI, 2021-10-27)Invasive lobular carcinoma (ILC) accounts for up to 15% of all breast cancer (BC) cases and responds well to endocrine treatment when estrogen receptor α-positive (ER+) yet differs in many biological aspects from other ER+ ... -
C/EBPα mediates the growth inhibitory effect of progestins on breast cancer cells.
Nacht, AS; Ferrari, R; Zaurin, R; Scabia, V; Carbonell-Caballero, J; et al. (WILEY, 2019-09-16)Steroid hormones are key gene regulators in breast cancer cells. While estrogens stimulate cell proliferation, progestins activate a single cell cycle followed by proliferation arrest. Here, we use biochemical and genome-wide ... -
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity.
Koch, C; Kuske, A; Joosse, SA; Yigit, G; Sflomos, G; et al. (WILEY, 2020-09-07)Functional studies giving insight into the biology of circulating tumor cells (CTCs) remain scarce due to the low frequency of CTCs and lack of appropriate models. Here, we describe the characterization of a novel CTC-derived ... -
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation.
Shamseddin, M; De Martino, F; Constantin, C; Scabia, V; Lancelot, A-S; et al. (WILEY, 2021-07-07)Hormonal contraception exposes women to synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progesterone and progestins affect the breast epithelium is poorly ... -
Deep Learning Enables Individual Xenograft Cell Classification in Histological Images by Analysis of Contextual Features.
Juppet, Q; De Martino, F; Marcandalli, E; Weigert, M; Burri, O; et al. (SPRINGER/PLENUM PUBLISHERS, 2021-06-01)Patient-Derived Xenografts (PDXs) are the preclinical models which best recapitulate inter- and intra-patient complexity of human breast malignancies, and are also emerging as useful tools to study the normal breast ... -
Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence.
Aouad, P; Zhang, Y; De Martino, F; Stibolt, C; Ali, S; et al. (NATURE PORTFOLIO, 2022-08-25)More than 70% of human breast cancers (BCs) are estrogen receptor α-positive (ER+). A clinical challenge of ER+ BC is that they can recur decades after initial treatments. Mechanisms governing latent disease remain elusive ... -
Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor.
Scabia, V; Ayyanan, A; De Martino, F; Agnoletto, A; Battista, L; et al. (NATURE PORTFOLIO, 2022-06-06)Estrogen and progesterone receptor (ER, PR) signaling control breast development and impinge on breast carcinogenesis. ER is an established driver of ER + disease but the role of the PR, itself an ER target gene, is debated. ... -
IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis.
Siersbæk, R; Scabia, V; Nagarajan, S; Chernukhin, I; Papachristou, EK; et al. (CELL PRESS, 2020-09-14)The cytokine interleukin-6 (IL6) and its downstream effector STAT3 constitute a key oncogenic pathway, which has been thought to be functionally connected to estrogen receptor α (ER) in breast cancer. We demonstrate that ... -
In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling.
George, AL; Boulanger, CA; Anderson, LH; Cagnet, S; Brisken, C; et al. (COMPANY OF BIOLOGISTS LTD, 2017-06-15)Amphiregulin (AREG)-/- mice demonstrate impaired mammary development and form only rudimentary ductal epithelial trees; however, AREG-/- glands are still capable of undergoing alveologenesis and lactogenesis during pregnancy. ... -
Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions.
Fiche, M; Scabia, V; Aouad, P; Battista, L; Treboux, A; et al. (WILEY, 2019-03-01)Estrogen receptor α-positive (ER-positive) or 'luminal' breast cancers were notoriously difficult to establish as patient-derived xenografts (PDXs). We and others recently demonstrated that the microenvironment is critical ... -
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1.
Sflomos, G; Battista, L; Aouad, P; De Martino, F; Scabia, V; et al. (WILEY, 2021-03-05)Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E-cadherin. It has clinical features distinct from other estrogen receptor-positive ... -
Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium.
Gagniac, L; Rusidzé, M; Boudou, F; Cagnet, S; Adlanmerini, M; et al. (COMPANY BIOLOGISTS LTD, 2020-03-11)17β-Estradiol induces the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ERα. ERα acts as a transcription factor but also elicits rapid signaling through a ... -
Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium.
Cagnet, S; Ataca, D; Sflomos, G; Aouad, P; Schuepbach-Mallepell, S; et al. (NATURE PUBLISHING GROUP, 2018-11-09)Oestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset of mammary ... -
Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma.
Sflomos, G; Schaumann, N; Christgen, M; Christgen, H; Bartels, S; et al. (MDPI, 2023-06-22)Invasive lobular carcinoma (ILC) is a common breast cancer subtype that is often diagnosed at advanced stages and causes significant morbidity. Late-onset secondary tumor recurrence affects up to 30% of ILC patients, posing ... -
RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer.
Staaf, J; Häkkinen, J; Hegardt, C; Saal, LH; Kimbung, S; et al. (NATURE PORTFOLIO, 2022-08-16)Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, subtypes, and ...