dc.contributor.author | Liu, J | |
dc.contributor.author | Lončar, I | |
dc.contributor.author | Collée, JM | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Michailidou, K | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Barile, M | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Behrens, S | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Boeckx, B | |
dc.contributor.author | Bogdanova, NV | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Brennan, P | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Broeks, A | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Chen, S-T | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Cheng, CY | |
dc.contributor.author | Choi, J-Y | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Cox, A | |
dc.contributor.author | Cross, SS | |
dc.contributor.author | Cuk, K | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Dos-Santos-Silva, I | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Figueroa, J | |
dc.contributor.author | Flyger, H | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Glendon, G | |
dc.contributor.author | Goldberg, MS | |
dc.contributor.author | González-Neira, A | |
dc.contributor.author | Guénel, P | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Hart, SN | |
dc.contributor.author | Hartman, M | |
dc.contributor.author | Hatse, S | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Ito, H | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | Kabisch, M | |
dc.contributor.author | Kang, D | |
dc.contributor.author | Kosma, V-M | |
dc.contributor.author | Kristensen, VN | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Lee, E | |
dc.contributor.author | Li, J | |
dc.contributor.author | Lophatananon, A | |
dc.contributor.author | Jan Lubinski, | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Matsuo, K | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | NBCS Collaborators, | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Perez, JIA | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Putti, TC | |
dc.contributor.author | Pylkäs, K | |
dc.contributor.author | Radice, P | |
dc.contributor.author | Sangrajrang, S | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Schneeweiss, A | |
dc.contributor.author | Shen, C-Y | |
dc.contributor.author | Shrubsole, MJ | |
dc.contributor.author | Shu, X-O | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Swerdlow, A | |
dc.contributor.author | Teo, SH | |
dc.contributor.author | Tessier, DC | |
dc.contributor.author | Thanasitthichai, S | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Torres, D | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Tseng, C-C | |
dc.contributor.author | Vachon, C | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Wu, AH | |
dc.contributor.author | Yannoukakos, D | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | van den Ouweland, AMW | |
dc.contributor.author | Martens, JWM | |
dc.contributor.author | Hollestelle, A | |
dc.date.accessioned | 2016-11-14T16:35:11Z | |
dc.date.issued | 2016-11-15 | |
dc.identifier.citation | Scientific reports, 2016, 6 pp. 36874 - ? | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/203 | |
dc.identifier.eissn | 2045-2322 | |
dc.identifier.doi | 10.1038/srep36874 | |
dc.description.abstract | NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r2 > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility. | |
dc.format | Electronic | |
dc.format.extent | 36874 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | NBCS Collaborators | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Cell Cycle Proteins | |
dc.subject | BRCA1 Protein | |
dc.subject | BRCA2 Protein | |
dc.subject | Nuclear Proteins | |
dc.subject | MicroRNAs | |
dc.subject | 3' Untranslated Regions | |
dc.subject | Odds Ratio | |
dc.subject | Risk Factors | |
dc.subject | Binding Sites | |
dc.subject | Genotype | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Alleles | |
dc.subject | Female | |
dc.title | rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-10-21 | |
rioxxterms.versionofrecord | 10.1038/srep36874 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-11-15 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Scientific reports | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.publication-status | Published | |
pubs.volume | 6 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Complex Trait Genetics | |
icr.researchteam | Aetiological Epidemiology | |
dc.contributor.icrauthor | Swerdlow, Anthony | |