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dc.contributor.authorLiu, Jen_US
dc.contributor.authorLončar, Ien_US
dc.contributor.authorCollée, JMen_US
dc.contributor.authorBolla, MKen_US
dc.contributor.authorDennis, Jen_US
dc.contributor.authorMichailidou, Ken_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorAndrulis, ILen_US
dc.contributor.authorBarile, Men_US
dc.contributor.authorBeckmann, MWen_US
dc.contributor.authorBehrens, Sen_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorBlomqvist, Cen_US
dc.contributor.authorBoeckx, Ben_US
dc.contributor.authorBogdanova, NVen_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorBrauch, Hen_US
dc.contributor.authorBrennan, Pen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorBroeks, Aen_US
dc.contributor.authorBurwinkel, Ben_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorChen, S-Ten_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.contributor.authorCheng, CYen_US
dc.contributor.authorChoi, J-Yen_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorCross, SSen_US
dc.contributor.authorCuk, Ken_US
dc.contributor.authorCzene, Ken_US
dc.contributor.authorDörk, Ten_US
dc.contributor.authorDos-Santos-Silva, Ien_US
dc.contributor.authorFasching, PAen_US
dc.contributor.authorFigueroa, Jen_US
dc.contributor.authorFlyger, Hen_US
dc.contributor.authorGarcía-Closas, Men_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorGlendon, Gen_US
dc.contributor.authorGoldberg, MSen_US
dc.contributor.authorGonzález-Neira, Aen_US
dc.contributor.authorGuénel, Pen_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorHamann, Uen_US
dc.contributor.authorHart, SNen_US
dc.contributor.authorHartman, Men_US
dc.contributor.authorHatse, Sen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorIto, Hen_US
dc.contributor.authorJakubowska, Aen_US
dc.contributor.authorKabisch, Men_US
dc.contributor.authorKang, Den_US
dc.contributor.authorKosma, V-Men_US
dc.contributor.authorKristensen, VNen_US
dc.contributor.authorLe Marchand, Len_US
dc.contributor.authorLee, Een_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorLophatananon, Aen_US
dc.contributor.authorJan Lubinskien_US
dc.contributor.authorMannermaa, Aen_US
dc.contributor.authorMatsuo, Ken_US
dc.contributor.authorMilne, RLen_US
dc.contributor.authorNBCS Collaboratorsen_US
dc.contributor.authorNeuhausen, SLen_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorOrr, Nen_US
dc.contributor.authorPerez, JIAen_US
dc.contributor.authorPeto, Jen_US
dc.contributor.authorPutti, TCen_US
dc.contributor.authorPylkäs, Ken_US
dc.contributor.authorRadice, Pen_US
dc.contributor.authorSangrajrang, Sen_US
dc.contributor.authorSawyer, EJen_US
dc.contributor.authorSchmidt, MKen_US
dc.contributor.authorSchneeweiss, Aen_US
dc.contributor.authorShen, C-Yen_US
dc.contributor.authorShrubsole, MJen_US
dc.contributor.authorShu, X-Oen_US
dc.contributor.authorSimard, Jen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorSwerdlow, Aen_US
dc.contributor.authorTeo, SHen_US
dc.contributor.authorTessier, DCen_US
dc.contributor.authorThanasitthichai, Sen_US
dc.contributor.authorTomlinson, Ien_US
dc.contributor.authorTorres, Den_US
dc.contributor.authorTruong, Ten_US
dc.contributor.authorTseng, C-Cen_US
dc.contributor.authorVachon, Cen_US
dc.contributor.authorWinqvist, Ren_US
dc.contributor.authorWu, AHen_US
dc.contributor.authorYannoukakos, Den_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorHall, Pen_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorHooning, MJen_US
dc.contributor.authorvan den Ouweland, AMWen_US
dc.contributor.authorMartens, JWMen_US
dc.contributor.authorHollestelle, Aen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2016-11-14T16:35:11Z
dc.date.issued2016-11-15en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/27845421en_US
dc.identifiersrep36874en_US
dc.identifier.citationSci Rep, 2016, 6 pp. 36874 - ?en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/203
dc.identifier.eissn2045-2322en_US
dc.identifier.doi10.1038/srep36874en_US
dc.description.abstractNBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r2 > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.en_US
dc.format.extent36874 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subject3' Untranslated Regionsen_US
dc.subjectAllelesen_US
dc.subjectBRCA1 Proteinen_US
dc.subjectBRCA2 Proteinen_US
dc.subjectBinding Sitesen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectCell Cycle Proteinsen_US
dc.subjectFemaleen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectGenotypeen_US
dc.subjectHumansen_US
dc.subjectMicroRNAsen_US
dc.subjectNuclear Proteinsen_US
dc.subjectOdds Ratioen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectRisk Factorsen_US
dc.titlers2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-10-21en_US
rioxxterms.versionofrecord10.1038/srep36874en_US
rioxxterms.licenseref.startdate2016-11-15en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfSci Repen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished onlineen_US
pubs.volume6en_US
pubs.embargo.termsNot knownen_US
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorOrr, Nicholasen_US


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