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dc.contributor.authorLiu, J
dc.contributor.authorLončar, I
dc.contributor.authorCollée, JM
dc.contributor.authorBolla, MK
dc.contributor.authorDennis, J
dc.contributor.authorMichailidou, K
dc.contributor.authorWang, Q
dc.contributor.authorAndrulis, IL
dc.contributor.authorBarile, M
dc.contributor.authorBeckmann, MW
dc.contributor.authorBehrens, S
dc.contributor.authorBenitez, J
dc.contributor.authorBlomqvist, C
dc.contributor.authorBoeckx, B
dc.contributor.authorBogdanova, NV
dc.contributor.authorBojesen, SE
dc.contributor.authorBrauch, H
dc.contributor.authorBrennan, P
dc.contributor.authorBrenner, H
dc.contributor.authorBroeks, A
dc.contributor.authorBurwinkel, B
dc.contributor.authorChang-Claude, J
dc.contributor.authorChen, S-T
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorCheng, CY
dc.contributor.authorChoi, J-Y
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCuk, K
dc.contributor.authorCzene, K
dc.contributor.authorDörk, T
dc.contributor.authorDos-Santos-Silva, I
dc.contributor.authorFasching, PA
dc.contributor.authorFigueroa, J
dc.contributor.authorFlyger, H
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorGiles, GG
dc.contributor.authorGlendon, G
dc.contributor.authorGoldberg, MS
dc.contributor.authorGonzález-Neira, A
dc.contributor.authorGuénel, P
dc.contributor.authorHaiman, CA
dc.contributor.authorHamann, U
dc.contributor.authorHart, SN
dc.contributor.authorHartman, M
dc.contributor.authorHatse, S
dc.contributor.authorHopper, JL
dc.contributor.authorIto, H
dc.contributor.authorJakubowska, A
dc.contributor.authorKabisch, M
dc.contributor.authorKang, D
dc.contributor.authorKosma, V-M
dc.contributor.authorKristensen, VN
dc.contributor.authorLe Marchand, L
dc.contributor.authorLee, E
dc.contributor.authorLi, J
dc.contributor.authorLophatananon, A
dc.contributor.authorJan Lubinski
dc.contributor.authorMannermaa, A
dc.contributor.authorMatsuo, K
dc.contributor.authorMilne, RL
dc.contributor.authorNBCS Collaborators
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorOrr, N
dc.contributor.authorPerez, JIA
dc.contributor.authorPeto, J
dc.contributor.authorPutti, TC
dc.contributor.authorPylkäs, K
dc.contributor.authorRadice, P
dc.contributor.authorSangrajrang, S
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmidt, MK
dc.contributor.authorSchneeweiss, A
dc.contributor.authorShen, C-Y
dc.contributor.authorShrubsole, MJ
dc.contributor.authorShu, X-O
dc.contributor.authorSimard, J
dc.contributor.authorSouthey, MC
dc.contributor.authorSwerdlow, A
dc.contributor.authorTeo, SH
dc.contributor.authorTessier, DC
dc.contributor.authorThanasitthichai, S
dc.contributor.authorTomlinson, I
dc.contributor.authorTorres, D
dc.contributor.authorTruong, T
dc.contributor.authorTseng, C-C
dc.contributor.authorVachon, C
dc.contributor.authorWinqvist, R
dc.contributor.authorWu, AH
dc.contributor.authorYannoukakos, D
dc.contributor.authorZheng, W
dc.contributor.authorHall, P
dc.contributor.authorDunning, AM
dc.contributor.authorEaston, DF
dc.contributor.authorHooning, MJ
dc.contributor.authorvan den Ouweland, AMW
dc.contributor.authorMartens, JWM
dc.contributor.authorHollestelle, A
dc.date.accessioned2016-11-14T16:35:11Z
dc.date.issued2016-11-15
dc.identifier.citationScientific reports, 2016, 6 pp. 36874 - ?
dc.identifier.issn2045-2322
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/203
dc.identifier.eissn2045-2322
dc.identifier.doi10.1038/srep36874
dc.description.abstractNBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r 2  > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.
dc.formatElectronic
dc.format.extent36874 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectNBCS Collaborators
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectCell Cycle Proteins
dc.subjectBRCA1 Protein
dc.subjectBRCA2 Protein
dc.subjectNuclear Proteins
dc.subjectMicroRNAs
dc.subject3' Untranslated Regions
dc.subjectOdds Ratio
dc.subjectRisk Factors
dc.subjectBinding Sites
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlleles
dc.subjectFemale
dc.titlers2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk.
dc.typeJournal Article
dcterms.dateAccepted2016-10-21
rioxxterms.versionofrecord10.1038/srep36874
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-11-15
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfScientific reports
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume6
pubs.embargo.termsNot known
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorOrr, Nicholasen


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